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Encyclopedia of Cancer pp 1–6Cite as

RET

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Definition

Rearranged during transfection: RET is the abbreviation for a gene that was found to be rearranged during transfection studies of NIH-3T3 cells with human lymphoma DNA. It is a receptor tyrosine kinase, for which the ligand is glial cell line-derived neurotrophic factors (GDNF). It was originally detected as an oncogenic version from a T-cell lymphoma.

Characteristics

RETis located on chromosome sub-band 10q11.2 and consists of at least 21 exons. Alternative polyadenylation sites and alternative splicing result in different transcript sizes. RET splice variants contain the first 19 exons, followed by distinct 3′ ends. These variants produce three protein isoforms that have 9 (RET9), 51 (RET51), or 43 (RET43) distinct amino acids at their C termini. The gene encodes for a transmembrane tyrosine kinase receptor. The first ten exons, and maybe part of exon 11, encode the extracellular domain; exon 11 encodes the transmembrane domain, while the remaining exons encode the...

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References

  • Airaksinen MS, Holm L, Hätinen T (2006) Evolution of the GDNF family ligands and receptors. Brain Behav Evol 68:181–190

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  • Asai N, Jijiwa M, Enomoto A et al (2006) RET receptor signaling: dysfunction in thyroid cancer and Hirschsprung’s disease. Pathol Int 56:164–172

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  • Gimm O (2001) Multiple endocrine neoplasia type 2: clinical aspects. Front Horm Res 28:103–130

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  • Santoro M, Melillo RM, Fusco A (2006) RET/PTC in papillary thyroid carcinoma: European journal of endocrinolgy prize lecture. Eur J Endocrinol 155:645–653

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  • Zbuk KM, Eng C (2007) Cancer phenomics: RET and PTEN as illustrative models. Nat Rev Cancer 7:35–45

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Author information

Authors and Affiliations

  1. Department of Surgery, University Hospital, Linköping, Sweden

    Oliver Gimm

Authors
  1. Oliver Gimm
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Correspondence to Oliver Gimm .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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Gimm, O. (2014). RET. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_5065-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_5065-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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