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Adjuvant Chemoendocrine Therapy

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Encyclopedia of Cancer

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Synonyms

Adjuvant chemohormonal therapy; Adjuvant cytotoxic therapy; Adjuvant hormonal therapy; Postsurgical systemic therapy

Definition

Adjuvant chemoendocrine therapy is a combination of chemotherapy and hormonal treatments that may be administered to patients after surgery for a nonmetastatic tumor with the goal of decreasing the risk of cancer recurrence.

Characteristics

Adjuvant chemoendocrine therapy is potentially useful for tumors which are responsive to both cytotoxic chemotherapy and hormonal interventions. The growth of these types of tumors is boosted by hormones and usually it may be limited not only by blocking these hormones but also by chemotherapy. Adjuvant chemoendocrine therapy is a standard treatment for early breast cancer, while it is experimental in prostate cancer, and it is not generally an option in other tumors with possible endocrine responsiveness such as endometrial cancer or ovarian cancer.

Breast Cancer

Surgery generally remains the first step for...

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References

  • Castiglione-Gertsch M, O’Neill A, Price KN et al (2003) International Breast Cancer Study Group adjuvant chemotherapy followed by goserelin versus either modality alone for premenopausal lymph node-negative breast cancer: a randomized trial. J Natl Cancer Inst 95(24):1833–1846

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  • Early Breast Cancer Trialist’ Collaborative Group (EBCTCG) (2005) Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 365:1687–1717

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  • Goldhirsh A, Wood WC, Gelber RD et al (2007) Progress and promise: highlight of International expert consensus on the primary therapy of early breast cancer. Ann Oncol 18(7):1133–1144

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  • Stearns V, Davidson NE (2004) Adjuvant chemotherapy and chemoendocrine therapy. In: Harris JR, Lippman ME, Morrow M, Osborne CK (eds) Disease of the breast, 3rd edn. Lippincott Williams & Wilkins, Philadelphia, pp 893–919

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Author information

Authors and Affiliations

  1. Department of Oncology, Instituto Scientifico Romagnolo per lo s, Infermi Hospital, Rimini, Italy

    Lorenzo Gianni, Alberto Ravaioli & Valentina Arcangeli

Authors
  1. Lorenzo Gianni
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  2. Alberto Ravaioli
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  3. Valentina Arcangeli
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Corresponding author

Correspondence to Lorenzo Gianni .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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© 2014 Springer-Verlag Berlin Heidelberg

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Gianni, L., Ravaioli, A., Arcangeli, V. (2014). Adjuvant Chemoendocrine Therapy. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_108-2

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_108-2

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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