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Adiponectin

  • Living reference work entry
  • First Online:
Encyclopedia of Cancer

  • 148 Accesses

Synonyms

ACDC; ACRP30; Adipocyte C1q and collagen domain containing; Adipocyte complement-related protein of 30 kDa; AdipoQ; Adipose most abundant gene transcript 1; aPM1; GBP28; Gelatin-binding protein 28

Definition

Adiponectin is a major adipokine secreted exclusively from adipocytes. This adipokine possesses insulin-sensitizing, antidiabetic, antiangiogenic, antiatherogenic, antiinflammatory and antitumorigenic properties.

Characteristics

Adiponectin was originally identified as an adipose-specific gene dysregulated in obesity. Human adiponectin gene is located on chromosome 3q27 and encodes a 244 amino acids polypeptide comprising of an NH2-terminal secretory signal sequence, followed by a hypervariable region, a collagenous domain, and a COOH-terminal globular domain (Fig. 1a). Circulating concentrations of adiponectin range from 3 to 30 μg/ml and account for about 0.05 % of total human blood proteins. Despite the fact that it is produced in adipose tissue, serum concentrations...

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References

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Authors and Affiliations

  1. Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong, China

    Jie Chen, Janice B. B. Lam & Yu Wang

Authors
  1. Jie Chen
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  2. Janice B. B. Lam
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  3. Yu Wang
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Corresponding author

Correspondence to Yu Wang .

Editor information

Editors and Affiliations

  1. Abt. Tumorgenetik, Deutsches Krebsforschungszentrum, Heidelberg, Germany

    Manfred Schwab

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Chen, J., Lam, J.B.B., Wang, Y. (2014). Adiponectin. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-27841-9_103-3

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  • DOI: https://doi.org/10.1007/978-3-642-27841-9_103-3

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Online ISBN: 978-3-642-27841-9

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