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Safety of Intravenous and Inhalation Anesthetics

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Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays

Abstract

The determination of safety of intravenous anesthetics first agents used as intravenous anesthetics were barbiturates. Barbiturates with a duration of action appropriate to the requirements of surgery became available with the introduction of hexobarbital and thiopental (Volwiler and Tabern 1930; Miller et al. 1936). The studies with barbiturates were extended (Butler and Bush 1942; Christensen and Lee 1973). Intravenous anesthetics from other chemical groups were developed, such as acetamidoeugenol (Estil, Domenjoz 1959), steroid derivatives (Presuren = hydroxydione sodium, Laubach et al. 1955), alfaxolone (CT1341, Child et al. 1971), propanidid (Epontol, Goldenthal 1971), ketamine (CI-581, Chen et al. 1966; Reich and Silvay 1989), etomidate (Janssen et al. 1975), propofol (ICI 35868, Glenn 1980), and midazolam (Pieri 1983; Reilly and Nimmo 1987).

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Authors and Affiliations

  1. Center for Sensory-Motor Interaction, Department of Health Science and Technology, School of Medicine, Aalborg University, Fredrik Bajers Vej 7, Bld. D3, Aalborg E, 9220, Denmark

    Dr. Lars Arendt-Nielsen

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  1. Dr. Lars Arendt-Nielsen
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Correspondence to Lars Arendt-Nielsen .

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  1. Sanofi Pharma Deutschland GmbH, A company of the Sanofi-Aventis Group Industriepark Hoechst, Frankfurt am Main, Germany

    Jochen Maas

  2. Dieburg, Germany

    Franz J. Hock

  3. Idstein, Germany

    Dieter Mayer

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Arendt-Nielsen, L. (2013). Safety of Intravenous and Inhalation Anesthetics. In: Vogel, H.G., Maas, J., Hock, F.J., Mayer, D. (eds) Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-25240-2_9

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