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Chronobiology and the Implications for Safety Pharmacology

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Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays

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Abstract

In order to get an insight into the mechanisms of action, efficacy, the pharmacokinetics, side effects, and toxicity of a compound for clinical use, it is essential to perform studies in animal models. In preclinical studies, rodents such as rats and mice serve as an important tool for drug development. In addition, dogs, monkeys, pigs, and some other large animals are of great importance in preclinical safety evaluation. Safety pharmacology is an essential part of this process. This review will concentrate on published data within these groups of experimental animals under the special focus whether and to what extent biological rhythms are involved in studies using these animal models.

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Acknowledgment

The research of B.L. was supported by several grants from the Deutsche Forschungsgemeinschaft and from PROCOP program of the European Community.

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  1. Institute of Experimental and Clinical Pharmacology and Toxicology, University of Heidelberg, Maybachstr. 14-16, 68169, Mannheim, Germany

    Dr. Björn Lemmer

  2. Incyte Corporation, Rt. 141 & Henry Clay Road, 19880, Wilmington, DE, USA

    Dr. Maxim Soloviev

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  1. Dr. Björn Lemmer
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Correspondence to Björn Lemmer .

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  1. Sanofi Pharma Deutschland GmbH, A company of the Sanofi-Aventis Group Industriepark Hoechst, Frankfurt am Main, Germany

    Jochen Maas

  2. Dieburg, Germany

    Franz J. Hock

  3. Idstein, Germany

    Dieter Mayer

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Lemmer, B., Soloviev, M. (2013). Chronobiology and the Implications for Safety Pharmacology. In: Vogel, H.G., Maas, J., Hock, F.J., Mayer, D. (eds) Drug Discovery and Evaluation: Safety and Pharmacokinetic Assays. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-25240-2_23

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