Abstract
In 1983, Robin Warren and Barry Marshall published their first papers in Lancet on unidentified curved bacilli on gastric epithelium in active chronic gastritis (Warren 1983; Marshall 1983). Dr Warren, a pathologist at the Royal Perth Hospital, had for several years observed a high occurrence of small curved and S-shaped bacilli and a closely associated granulocyte infiltration in gastric biopsies. He believed that they played a role in gastric disease. Dr Marshall, a gastroenterology fellow, was attracted by the hypothesis and persuaded Dr Warren to make further investigations. They noted that, although the bacilli could not be classified by reference to Bergey’s Manual of Determinative Bacteriology they resembled campylobacters more than spirochetes. By using microaerophilic campylobacter isolation techniques, Warren and Marshall achieved the first ever culture of the bacterium from human gastric biopsies in their 35th attempt in 1982. Because of a MRSA epidemic at the Royal Perth Hospital this H. pylori culture was not read until after the Eastern weekend (Kidd and Modlin 1998; Barry Marshall, personal communication 2005).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Bayerdörffer E, Neubauer A, Rudolph B, Thiede C, Lehn N, Eidt S, Stolte M, MALT Lymphoma Study Group. Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection. Lancet. 1995;345(8965):1591–4.
Bergenzaun P, Kristinsson KG, Thjodleifsson B, Sigvaldadottir E, Molstad S, Held M, Wadström T. Seroprevalence of Helicobacter pylori in south Sweden and Iceland. Scand J Gastroenterol. 1996;31:1157–61.
Blot WJ, Devesa SS, Kneller RW, Fraumeni Jr JF. Rising incidence of adenocarcinoma of the esophagus and gastric cardia. JAMA. 1991;265:1287–9.
Brenner H, Bode G, Adler G, Rothenbacher D. Does maternal smoking hinder mother-child transmission of Helicobacter pylori infection? Epidemiology. 2000;11:71–5.
Censini S, Lange C, Xiang Z, Crabtree JE, Ghiara P, Borodovsky M, Rappuoli R, Covacci A. cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proc Natl Acad Sci USA. 1996;93:14648–53.
Coghlan JG, Gilligan D, Humphries H, McKenna D, Dooley C, Sweeney E, Keane C, O’Morain C. Campylobacter pylori and recurrence of duodenal ulcers–a 12-month follow-up study. Lancet. 1987;2:1109–11.
Correa P, Haenzel W, Cuello C, Zavala D, Fontham E, Zarama G, Tannenbaum S, Collazoz T, Ruiz B. Gastric precancerous process in high risk population: cross-sectional studies. Cancer Res. 1990;50:4731–6.
Correa P. The biological model of gastric carcinogenesis. IARC Sci Publ. 2004;157:301–10.
Falush D, Kraft C, Taylor NS, Correa P, Fox JG, Achtman M, Suerbaum S. Recombination and mutation during long-term gastric colonization by Helicobacter pylori: estimates of clock rates, recombination size, and minimal age. Proc Natl Acad Sci USA. 2001;98:15056–61.
Farinha P, Gascoyne RD. Helicobacter pylori and MALT lymphoma. Gastroenterology. 2005;128:1579–605.
Ferlay J, Bray F, Pisani P, Parkin DM. GLOBOCAN 2000: Cancer incidence, mortality and prevalence worldwide, version 1.0. Lyon: IARCPress, IARC CancerBase 2001: No. 5.
Franceschi S, La Vecchia C. Alcohol and the risk of cancers of the stomach and colon-rectum. Dig Dis. 1994;12:276–89.
Frenck Jr RW, Clemens J. Helicobacter in the developing world. Microbes Infect. 2003;5:705–13.
Gonzalez CA, EPIC Working Group on Gastric Cancer. Vegetable, fruit and cereal consumption and gastric cancer risk. IARC Sci Publ. 2002;156:79–83.
Goodwin CS, Worsley BW. Microbiology of Helicobacter pylori. Gastroenterol Clin North Am. 1993;22:5–19.
Han SR, Zschausch HC, Meyer HG, Schneider T, Loos M, Bhakdi S, Maeurer MJ. Helicobacter pylori: clonal population structure and restricted transmission within families revealed by molecular typing. J Clin Microbiol. 2000;38:3646–51.
Hansson LE, Nyrén O, Hsing AW, Bergström R, Josefsson S, Chow WH, Fraumeni Jr JF, Adami HO. The risk of stomach cancer in patients with gastric or duodenal ulcer disease. N Engl J Med. 1996;335:242–9.
Helicobacter and Cancer Collaborative Group. Gastric cancer and Helicobacter pylori: a combined analysis of 12 case control studies nested within prospective cohorts. Gut. 2001;49:347–53.
Higashi H, Tsutsumi R, Muto S, Sugiyama T, Azuma T, Asaka M, Hatakeyama M. SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science. 2002;295:683–6.
Howson CP, Hiyama T, Wynder EL. The decline in gastric cancer: epidemiology of an unplanned triumph. Epidemiol Rev. 1986;8:1–27.
Johan G, Offerhaus A, Molyvas EN, Hoedemaeker PJ. Helicobacter pylori infection of gastric mucin cell metaplasia: the duodenum revisited. J Pathol. 1990;162:239–43.
Keller G, Vogelsang H, Becker I, Plaschke S, Ott K, Suriano G, Mateus AR, Seruca R, Biedermann K, Huntsman D, Döring C, Holinski-Feder E, Neutzling A, Siewert JR, Höfler H. Germline mutations of the E-cadherin(CDH1) and TP53 genes, rather than of RUNX3 and HPP1, contribute to genetic predisposition in German gastric cancer patients. J Med Genet. 2004;41:e89–95.
Kelley JR, Duggan JM. Gastric cancer epidemiology and risk factors. J Clin Epidemiol. 2003;56:1–9.
Kidd M, Modlin IM. A century of Helicobacter pylori: paradigms lost – paradigms regained. Digestion. 1998;59:1–15.
Kivi M, Tindberg Y, Sörberg M, Casswall TH, Befrits R, Hellström PM, Bengtsson C, Engstrand L, Granström M. Concordance of Helicobacter pylori strains within families. J Clin Microbiol. 2003;41:5604–8.
Kyriazanos I, Ilias I, Lazaris G, Hountis P, Deros I, Dafnopoulou A, Datsakis K. A cohort study on Helicobacter pylori serology before and after induction in the Hellenic Navy. Mil Med. 2001;166:411–5.
La Vecchia C, Negri E, D’Avanzo B, Franceschi S. Electric refrigerator use and gastric cancer risk. Br J Cancer. 1990;62:136–7.
Labenz J, Borsch G. Highly significant change of the clinical course of relapsing and complicated peptic ulcer disease after cure of Helicobacter pylori infection. Am J Gastroenterol. 1994;89:1785–8.
Laurén P. The two histological main types of gastric carcinoma: diffuse and so-called intestinal-type carcinoma: an attempt at a histo-clinical classification. APMIS. 1965;64:31–49.
Lee SH, Kim HS, Kim SY, Lee YS, Park WS, Kim SH, Lee JY, Yoo NJ. Increased expression of FLIP, an inhibitor of Fas mediated apoptosis, in stomach cancer. APMIS. 2003;111:309–14.
Lindkvist P, Wadstrom T, Giesecke J. Helicobacter pylori infection and foreign travel. J Infect Dis. 1995;172:1135–6.
Lindor NM, Greene MH. The concise handbook of family cancer syndromes. Mayo Familial Cancer Program. J Natl Cancer Inst. 1998;90:1039–71.
Luzza F, Mancuso M, Imeneo M, Contaldo A, Giancotti L, Pensabene L, Doldo P, Liberto MC, Strisciuglio P, Foca A, Guandalini S, Pallone F. Evidence favouring the gastro-oral route in the transmission of Helicobacter pylori infection in children. Eur J Gastroenterol Hepatol. 2000;12:623–7.
Lynch DA, Mapstone NP, Clarke AM, Sobala GM, Jackson P, Morrison L, Dixon MF, Quirke P, Axon AT. Cell proliferation in Helicobacter pylori associated gastritis and the effect of eradication therapy. Gut. 1995;36:346–50.
Malaty HM, El-Kasabany A, Graham DY, Miller CC, Reddy SG, Srinivasan SR, Yamaoka Y, Berenson GS. Age at acquisition of Helicobacter pylori infection: a follow-up study from infancy to adulthood. Lancet. 2002;359:931–5.
Marshall B. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet. 1983;1(8336):1273–5.
McKnight GM, Duncan CW, Leifert C, Golden MH. Dietary nitrate in man: friend or foe? Br J Nutr. 1999;81:349–58.
Molloy RM, Sonnenberg A. Relation between gastric cancer and previous peptic ulcer disease. Gut. 1997;40:247–52.
Morad M, Merrick J, Nasri Y. Prevalence of Helicobacter pylori in people with intellectual disability in a residential care centre in Israel. J Intellect Disabil Res. 2002;46:141–3.
Odenbreit S, Gebert B, Püls J, Fischer W, Haas R. Interaction of Helicobacter pylori with professional phagocytes: role of the cag pathogenicity island and translocation, phosphorylation and processing of CagA. Cell Microbiol. 2001;3:21–31.
Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55:74–108.
Parsonnet J, Hansen S, Rodriguez L, Gelb A, Warnke R, Jellum E, Orentreich N, Vogelman J, Friedman G. Helicobacter pylori infection and gastric lymphoma. N Engl J Med. 1994;330:1267–71.
Pobel D, Riboli E, Cornee J, Hemon B, Guyader M. Nitrosamine, nitrate and nitrite in relation to gastric cancer: a case-control study in Marseille, France. Eur J Epidemiol. 1995;11:67–73.
Riboli E, Norat T. Epidemiologic evidence of the protective effect of fruit and vegetables on cancer risk. Am J Clin Nutr. 2003;78(3 Suppl):559S–69.
Rothenbacher D, Brenner H. Burden of Helicobacter pylori and H. pylori-related diseases in developed countries: recent developments and future implications. Microbes Infect. 2003;5:693–703.
Rowland M, Kumar D, Daly L, O’Connor P, Vaughan D, Drumm B. Low rates of Helicobacter pylori reinfection in children. Gastroenterology. 1999;117:336–41.
Scott DR, Weeks D, Hong C, Postius S, Melchers K, Sachs G. The role of internal urease in acid resistance of Helicobacter pylori. Gastroenterology. 1998;114:58–70.
Steinberg EB, Mendoza CE, Glass R, Arana B, Lopez MB, Mejia M, Gold BD, Priest JW, Bibb W, Monroe SS, Bern C, Bell BP, Hoekstra RM, Klein R, Mintz ED, Luby S. Prevalence of infection with waterborne pathogens: a seroepidemiologic study in children 6–36 months old in San Juan Sacatepequez, Guatemala. Am J Trop Med Hyg. 2004;70:83–8.
Tersmette AC, Giardiello FM, Tytgat GN, Offerhaus GJ. Carcinogenesis after remote peptic ulcer surgery: the long-term prognosis of partial gastrectomy. Scand J Gastroenterol Suppl. 1995;212:96–9.
Tomb JF, White O, Kerlavage AR, Clayton RA, Sutton GG, Fleischmann RD, Ketchum KA, Klenk HP, Gill S, Dougherty BA, Nelson K, Quackenbush J, Zhou L, Kirkness EF, Peterson S, Loftus B, Richardson D, Dodson R, Khalak HG, Glodek A, McKenney K, Fitzegerald LM, Lee N, Adams MD, Hickey EK, Berg DE, Gocayne JD, Utterback TR, Peterson JD, Kelley JM, Cotton MD, Weidman JM, Fujii C, Bowman C, Watthey L, Wallin E, Hayes WS, Borodovsky M, Karp PD, Smith HO, Fraser CM, Venter JC. The complete genome sequence of the gastric pathogen Helicobacter pylori. Nature. 1997;388:539–47.
Trédaniel J, Boffetta P, Buiatti E, Saracci R, Hirsch A. Tobacco smoking and gastric cancer: review and meta-analysis. Int J Cancer. 1997;72:565–73.
Tsugane S. Salt, salted food intake, and risk of gastric cancer: epidemiologic evidence. Cancer Sci. 2005;96:1–6.
Warren JR. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet. 1983;1(8336):1273.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2013 Springer-Verlag Berlin Heidelberg
About this entry
Cite this entry
Simán, H., Florén, CH. (2013). The Gastroenterologist View. In: Hamm, B., Ros, P.R. (eds) Abdominal Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-13327-5_203
Download citation
DOI: https://doi.org/10.1007/978-3-642-13327-5_203
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-13326-8
Online ISBN: 978-3-642-13327-5
eBook Packages: MedicineReference Module Medicine