Abstract
It is generally considered that only unbound drug in the plasma elicits a pharmacological response. Therefore, it follows that unbound concentrations of drug should correlate better with safety and efficacy than total plasma concentrations when the free fraction is subject to change.
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© 2011 Springer-Verlag Berlin Heidelberg
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Shackleton, G. (2011). Special Populations: Protein Binding Aspects. In: Vogel, H.G., Maas, J., Gebauer, A. (eds) Drug Discovery and Evaluation: Methods in Clinical Pharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-89891-7_10
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DOI: https://doi.org/10.1007/978-3-540-89891-7_10
Publisher Name: Springer, Berlin, Heidelberg
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