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Pediatric Nephrology pp 667–702Cite as

Idiopathic Nephrotic Syndrome in Children: Clinical Aspects

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Abstract

In children, the most common cause of nephrotic syndrome is idiopathic nephrotic syndrome (INS), also called nephrosis (1). INS is defined by the combination of a nephrotic syndrome (proteinuria, hypoalbuminemia, hyperlipidemia, and edema) and non-specific histological abnormalities of the kidney including minimal changes, focal and segmental glomerular sclerosis (FSGS), and diffuse mesangial proliferation. Glomeruli show a fusion of epithelial cell foot processes on electron microscopy and no significant deposits of immunoglobulins or complement on immunofluorescence.

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Authors and Affiliations

  1. Service de Néphrologie Pédiatrique, Hôpital Necker-Enfants Malades, Paris, France

    Patrick Niaudet & Olivia Boyer

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  1. Patrick Niaudet
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  2. Olivia Boyer
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Editors and Affiliations

  1. Medical College of Wisconsin, Wisconsin, USA

    Ellis Avner (Director, Children's Research Institute, CHHS, Associate Dean for Research, Professor of Pediatrics and Physiology) (Director, Children's Research Institute, CHHS, Associate Dean for Research, Professor of Pediatrics and Physiology)

  2. Harvard Medical School, Children's Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts, 02115, USA

    William Harmon (Professor of Pediatrics, Director, Pediatric Nephrology) (Professor of Pediatrics, Director, Pediatric Nephrology)

  3. Service de Néphrologie Pédiatrique Centre de référence des Maladies Rénales Héréditaires de l'Enfant et de l'Adulte (MARHEA), Hôpital Necker‐Enfants Malades, 149, rue de Sèvres, 75743, Paris Cedex 15, France

    Patrick Niaudet

  4. Department of Pediatrics Wakayama Medical University, Wakayama Medical University Hospital, 641–8510811–1, Kimiidera, Wakayama City, Japan

    Norishige Yoshikawa (Professor and Chair Pediatrician‐in‐Chief) (Professor and Chair Pediatrician‐in‐Chief)

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Niaudet, P., Boyer, O. (2009). Idiopathic Nephrotic Syndrome in Children: Clinical Aspects. In: Avner, E., Harmon, W., Niaudet, P., Yoshikawa, N. (eds) Pediatric Nephrology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-76341-3_28

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  • DOI: https://doi.org/10.1007/978-3-540-76341-3_28

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