Abstract
The study of population genetics can contribute to paleoanthropological research in three ways. First, the analysis of genetic variation in living human populations can provide information about past events, including the time and place of recent common ancestors, which when considered over many loci can give us clues regarding patterns of human evolution. Recent work in this area supports a view of several dispersions out of Africa, with the later two corresponding roughly to the appearance of the morphospecies Homo heidelbergensis and modern H. sapiens, but in both cases showing evidence of dispersions with admixture, rather than dispersions with replacement. Second, studies of ancient DNA, such as those conducted to date on Neandertal fossils, can potentially give us insight into ancient genetic variation and relationships among populations or taxa. Evidence to date suggests that Neandertals may have contributed little in overall ancestry to living humans, but it is still not clear whether they contributed nothing genetically. Third, mathematical models and simulations based on population genetic theory can help us formulate and refine hypotheses regarding human evolution by providing an idea of what patterns should be expected in the fossil record under alternative evolutionary scenarios.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Adcock GJ, Dennis ES, Easteal S, Huttley GA, Jermiin LS, Peacock WJ, Thorne A (2001a) Human origins and ancient human DNA. Science 292: 1656
Adcock GJ, Dennis ES, Huttley GA, Jermiin LS, Peacock WJ, Thorne A (2001b) Mitochondrial DNA sequences in ancient Australians: Implications for modern human origins. Proc Natl Acad Sci USA 98: 537–542
Bräuer G (1992) Africa's place in the evolution of Homo sapiens. In: Bräuer G, Smith FH (eds) Continuity or replacement: Controversies in Homo sapiens evolution. AA Balkema, Rotterdam, pp 83–98
Cann RL, Stoneking M, Wilson A (1987) Mitochondrial DNA and human evolution. Nature 325: 31–36
Caramelli D, Lalueza-Fox C, Vernesi C, Casoli A, Mallegni F, Chiarelli B, Dupanloup I, Bertranpetit J, Barbujani G, Bertorelle G (2003) Evidence for a genetic discontinuity between Neandertals and 24,000-year-old anatomically modern Europeans. Proc Natl Acad Sci USA 100: 6593–6597
Cooper A, Rambaut A, Macaulay V, Willerslev E, Hansen AJ, Stringer C (2001) Human origins and ancient human DNA. Science 292: 1655–1656
Currat M, Excoffier L (2004) Modern humans did not admix with Neanderthals during their range expansion into Europe. PLoS Biol 2(12): e421
Duarte C, MaurÃcio J, Pettitt PB, Souto P, Trinkaus E, van der Plicht H, Zilhão J (1999) The early Upper Paleolthic human skeleton from the Abrigo do Lagar Velho (Portugal) and modern human emergence in Iberia. Proc Natl Acad Sci USA 96: 7604–7609
Eswaran V (2002) A diffusion wave out of Africa: The mechanism of the modern human revolution? Curr Anthropol 43: 749–774
Gutiérrez G, Sánchez D, Marin A (2002) A reanalysis of the ancient mitochondrial DNA sequences recovered from Neandertal bones. Mol Biol Evol 19: 1359–1366
Hartl DL, Clark AG (1997) Principles of population genetics. Sinauer Associates, Sunderland, MA
Hassan FA (1981) Demographic archaeology. Academic Press, New York
Jorde LB, Bamshad MJ, Watkins WS, Zenger R, Fraley AE, Krakowiak PA, Carpenter KD, Soodyall H, Jenkins R, Rogers AR (1995) Origins and affinities of modern humans: A comparison of mitochondrial and nuclear genetic data. Am J Hum Genet 57: 523–538
Klein J, Takahata N (2002) Where do we come from? The molecular evidence for human descent. Springer-Verlag, Berlin
Krings M, Stone A, Schmitz RW, Krainitzki H, Stoneking M, Pääbo S (1997) Neandertal DNA sequences and the origin of modern humans. Cell 90: 19–30
Krings M, Geisert H, Schmitz RW, Krainitzki H, Pääbo S (1999) DNA sequence of the mitochondrial hypervariable region II from the Neandertal type specimen. Proc Natl Acad Sci USA 96: 5581–5585
Krings M, Capelli C, Tschentscher F, Geisert H, Meyer S, von Haeseler A, Grossschmidt K, Possnert G, Paunovic M, Pääbo S (2000) A view of Neandertal genetic diversity. Nat Genet 26: 144–146
Lahr MM (1994) The multiregional model of modern human origins: A reassessment of the morphological basis. J Hum Evol 26: 23–56
Lahr MM (1996) The evolution of modern human diversity: A study of cranial variation. Cambridge University Press, Cambridge
Lewin R (1987) Bones of contention: Controversies in the search for human origins. University of Chicago Press, Chicago
Marth G, Schuler G, Yeh R, Davenport R, Agarwala R, Church D, Wheelan S, Baker J, Ward M, Kholodov M, Phan L, Czabarka E, Murvai J, Cutler D, Wooding S, Rogers A, Chakravati A, Harpending HC, Kwok P-Y, Sherry ST (2003) Sequence variations in the public human genome data reflect a bottlenecked population history. Proc Natl Acad Sci USA 100: 376–381
McDougall I, Brown FH, Fleagle JG (2005) Stratigraphic placement and age of modern humans from Kibish, Ethiopia. Nature 433: 733–736
Ovchinnikov IV, Götherström A, Romanova GP, Kharitonov VM, Lidén K, Goodwin W (2000) Molecular analysis of Neanderthal DNA from the northern Caucasus. Nature 404: 490–493
Penny D, Steel M, Waddell PJ, Hendy MD (1995) Improved analyses of human mtDNA sequences support a recent African origin for Homo sapiens. Mol Biol Evol 12: 863–882
Reed DL, Smith VC, Hammond SL, Rogers AR, Clayton DH (2004) Genetic analysis of lice supports direct contact between modern and archaic humans. PLoS Biol 2(11): e340
Relethford JH (1999) Models, predictions, and the fossil record of modern human origins. Evol Anthropol 8: 7–10
Relethford JH (2000) Human skin color diversity is highest in sub-Saharan African populations. Hum Biol 72: 773–780
Relethford JH (2001a) Absence of regional affinities of Neandertal DNA with living humans does not reject multiregional evolution. Am J Phys Anthropol 115: 95–98
Relethford JH (2001b) Ancient DNA and the origin of modern humans. Proc Natl Acad Sci USA 98: 390–391
Relethford JH (2001c) Genetics and the search for modern human origins. Wiley-Liss, New York
Relethford JH (2003) Reflections of our past: How human history is revealed in our genes. Westview Press, Boulder
Relethford JH, Harpending HC (1994) Craniometric variation, genetic theory, and modern human origins. Am J Phys Anthropol 95: 249–270
Relethford JH, Jorde LB (1999) Genetic evidence for larger African population size during recent human evolution. Am J Phys Anthropol 108: 251–260
Roberts DF, Hiorns RW (1962) The dynamics of racial admixture. Am J Hum Genet 14: 261–277
Rogers AR, Jorde LB (1995) Genetic evidence on modern human origins. Hum Biol 67: 1–36
Sarich VM, Wilson A (1967) Immunological time scale for hominoid evolution. Science 158: 1200–1203
Schmitz RW, Serre D, Bonani G, Feine S, Hillgruber F, Krainitzki H, Pääbo S, Smith FH (2002) The Neandertal type site revisited: Interdisciplinary investigations of skeletal remains from the Neander Valley, Germany. Proc Natl Acad Sci USA 99: 13342–13347
Serre D, Langaney A, Checkh M, Teschler- Nicola M, Paunovic M, Mennecier P, Hofreiter M, Possnert G, Pääbo S (2004) No evidence of Neandertal mtDNA contribution to early modern humans. PLoS Biol 2(3): e57
Smith FH, Falsetti AB, Donnelly SM (1989) Modern human origins. Yrbk Phys Anthropol 32: 35–68
Sokal RR, Oden NL, Walker J, Waddle DM (1997) Using distance matrices to choose between competing theories and an application to the origin of modern humans. J Hum Evol 32: 501–522
Stoneking M (1993) DNA and recent human evolution. Evol Anthropol 2: 60–73
Stringer CB (1993) Reconstructing human evolution. In: Aitken MJ, Stringer CB, Mellars PA (eds) The origin of modern humans and the impact of chronometric dating. Princeton University Press, Princeton, pp 179–195
Takahata N, Lee S-H, Satta Y (2001) Testing multiregionality of modern human origins. Mol Biol Evol 18: 172–183
Tattersall I (1995) The fossil trail: How we know what we think we know about human evolution. Oxford University Press, New York
Tattersall I, Schwartz JH (1999) Hominids and hybrids: The place of Neanderthals in human evolution. Proc Natl Acad Sci USA 96: 7117–7119
Templeton AR (2002) Out of Africa again and again. Nature 416: 45–51
Templeton AR (2004) A maximum likelihood framework for cross validation of phylogeographic hypotheses. In: Wasser SP (ed) Evolutionary theory and processes: Modern horizons. Kluwer Academic Publishers, Dordrecht The Netherlands, pp 209–230
Thorne AG, Wolpoff MH, Eckhardt RB (1993) Genetic variation in Africa. Science 261: 1507–1508
Tishkoff SA, Dietzsch E, Speed W, Pakstit AJ, Kidd JR, Cheung K, Bonné-Tamir B, Santachiara-Benerecetti AS, Moral P, Krings M, Pääbo S, Watson E, Risch N, Jenkins T, Kidd KK (1996) Global patterns of linkage disequilibrium at the CD4 locus and modern human origins. Science 271: 1380–1387
Trinkaus E, Zilhão J (2002) Phylogenetic interpretations. In: Zilhão J, Trinkaus E (eds) Portrait of the artist as a child: The Gravettian human skeleton from the Abrigo do Lagar Velho and its archaeological context. Instituto Português de Arqueologia, Lisbon, pp 497–518
Trinkaus E, Moldovan O, Milota S, Bilgăr A, Sarcina L, Athreya S, Bailey SE, Rodrigo R, Mircea G, Higham T, Ramsey CB, van der Plicht J (2003) An early modern human from the Pestera cu Oase, Romania. Proc Natl Acad Sci USA 100: 11231–11236
Vigilant L, Stoneking M, Harpending H, Hawkes K, Wilson AC (1991) African populations and the evolution of human mitochondrial DNA. Science 253: 1503–1507
Waddle DM (1994) Matrix correlation tests support a single origin for modern humans. Nature 368: 452–454
Wall JD (2000) Detecting ancient admixture in humans using sequence polymorphisms data. Genetics 154: 1271–1279
Watkins WS, Ricker CE, Bamshad MJ, Carroll ML, Nguyen SV, Batzer MA, Harpending HC, Rogers AR, Horde LB (2001) Patterns of ancestral human diversity: An analysis of Alu-insertion and restriction-site polymorphisms. Am J Hum Genet 68: 738–752
Wolpoff MH (1999) Paleoanthropology, 2nd edn. McGraw-Hill, New York
Wolpoff MH, Thorne AG, Smith FH, Frayer DW, Pope GG (1994) Multiregional evolution: A world-wide source for modern human populations. In: Nitecki MH, Nitecki DV (eds) The origin of anatomically modern humans. Plenum Press, New York, pp 175–199
White TD, Asfaw B, De Gusta D, Gilbert H, Richards GD, Howell FC (2003) Pleistocene Homo sapiens from Middle Awash, Ethiopia. Nature 423: 742–747
Wright S (1931) Evolution in Mendelian populations. Genetics 16: 97–159
Rights and permissions
Copyright information
© 2007 Springer-Verlag Berlin Heidelberg New York
About this entry
Cite this entry
Relethford, J.H. (2007). 20 Population Genetics and Paleoanthropology. In: Handbook of Paleoanthropology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-33761-4_20
Download citation
DOI: https://doi.org/10.1007/978-3-540-33761-4_20
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-32474-4
Online ISBN: 978-3-540-33761-4
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences