Encyclopedia of Pain

2007 Edition

Adequate Stimulus

Reference work entry
DOI: https://doi.org/10.1007/978-3-540-29805-2_97


A term coined by Sherrington in 1890's to define the optimal stimulus for the activation of a particular nervous system structure. For nociceptive systems in humans it is simply defined as „a pain-producing stimulus“ – for animal studies it has been defined as a stimulus that produces, or threatens to produce, tissue damage. This is valid for studies of skin sensation, but may not be valid for deep tissues such as viscera.

 Nocifensive Behaviors of the Urinary Bladder

 Visceral Pain Model, Urinary Bladder Pain (Irritants or Distension)

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© Springer-Verlag Berlin Heidelberg 2007