Synonyms
AAV
Definition
Adenoassociated virus (AAV) based vectors are derived from a non-pathogenic parvovirus. AAV are thought to be naturally defective, because of their requirement for co-infection with a helper virus, such as Ad or HSV, for a productive infection. The single stranded 4.7 kB DNA genome is packaged in a 20 nm particle. AAV is not associated with any known disease and induces very little immune reaction when used as a vector. For applications requiring a relatively small transgene, AAV vectors are very attractive, but the small insert capacity limits their utility for applications requiring a large transgene.
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© 2007 Springer-Verlag Berlin Heidelberg
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(2007). Adenoassociated Virus Vectors. In: Schmidt, R., Willis, W. (eds) Encyclopedia of Pain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29805-2_92
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DOI: https://doi.org/10.1007/978-3-540-29805-2_92
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-43957-8
Online ISBN: 978-3-540-29805-2
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