Skip to main content

Acute Pain Mechanisms

  • Reference work entry
Encyclopedia of Pain
  • 88 Accesses

Definition

Acute pain is defined as “pain of recent onset and probable limited duration. It usually has an identifiable temporal and causal relationship to injury or disease” (Ready and Edwards 1992). The perception of acute pain requires transduction of noxious mechanical, thermal or chemical stimuli by nociceptive neurons, integration and modulation at the level of the spinal cord and ultimately transmission to cortical centres.

Characteristics

Peripheral Nociception

Nociceptors in the skin and other deeper somatic tissues such as periosteum are morphologically free nerve endings or simple receptor structures. A noxious stimulus activates the nociceptor depolarising the membrane viaa variety of stimulus specific transduction mechanisms. C polymodal nociceptors are the most numerous of somatic nociceptors and respond to a full range of mechanical, chemical and thermal noxious stimuli. Polymodal nociceptors are coupled to unmyelinated C fibres. Electrophysiological activity in these...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 1,250.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Basbaum AI, Jessel TM (2000) The perception of pain. In: Kandel ER, Schwartz JH, Jessell TM (eds) Principles of Neural Science. McGraw-Hill, New York, pp 472–91

    Google Scholar 

  2. Fürst S (1999) Transmitters involved in antinociception in the spinal cord. Brain Res Bull 48:129–41

    Google Scholar 

  3. Julius D, Basbaum AI (2001) Molecular mechanisms of nociception. Nature 413:203–7

    Google Scholar 

  4. Kidd BL, Urban L (2001) Mechanisms of Inflammatory Pain. Br J Anaesth 87:3–11

    Google Scholar 

  5. McBain CJ, Mayer ML (1994) N-methyl-d-aspartic acid receptor structure and function. Physiol Rev 74:723–60

    Google Scholar 

  6. Parent A (1996) Carpenter’s Human Neuroanatomy. Williams & Wilkins, Baltimore

    Google Scholar 

  7. Ready LB, Edwards WT (1992) Management of Acute Pain: A Practical Guide. Taskforce on Acute Pain. IASP Publications, Seattle

    Google Scholar 

  8. Smullen DH, Skilling SR, Larson AA (1990) Interactions between Substance P, calcitonin G related peptide taurine and excitatory amino acids in the spinal cord. Pain 42:93–101

    Google Scholar 

  9. Treede R-D, Kenshalo DR, Gracely RH et al. (1999) The cortical representation of pain. Pain 79:105–11

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer-Verlag Berlin Heidelberg

About this entry

Cite this entry

Murphy, P. (2007). Acute Pain Mechanisms. In: Schmidt, R., Willis, W. (eds) Encyclopedia of Pain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29805-2_72

Download citation

  • DOI: https://doi.org/10.1007/978-3-540-29805-2_72

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-43957-8

  • Online ISBN: 978-3-540-29805-2

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics