Encyclopedia of Pain

2007 Edition

Axon Reflex

Reference work entry
DOI: https://doi.org/10.1007/978-3-540-29805-2_353


The activation of a nociceptive C-fiber results not only in the transmission of action potentials towards the CNS, but also along its branching fibers back towards the skin. This leads to the release of the vasoactive substances CGRP (calcitonin-gene-related peptide) and substance P. These neuropeptides subsequently induce protein extravasation and vasodilation, which is reddening and weal formation of the skin (neurogenic inflammation).

 Autologous Thrombocyte Injection as a Model of Cutaneous Pain

 Nociceptor, Axonal Branching

 Nociceptors in the Dental Pulp

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© Springer-Verlag Berlin Heidelberg 2007