Definition
The activation of a nociceptive C-fiber results not only in the transmission of action potentials towards the CNS, but also along its branching fibers back towards the skin. This leads to the release of the vasoactive substances CGRP (calcitonin-gene-related peptide) and substance P. These neuropeptides subsequently induce protein extravasation and vasodilation, which is reddening and weal formation of the skin (neurogenic inflammation).
Autologous Thrombocyte Injection as a Model of Cutaneous Pain
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© 2007 Springer-Verlag Berlin Heidelberg
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(2007). Axon Reflex. In: Schmidt, R., Willis, W. (eds) Encyclopedia of Pain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29805-2_353
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DOI: https://doi.org/10.1007/978-3-540-29805-2_353
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-43957-8
Online ISBN: 978-3-540-29805-2
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