Encyclopedia of Pain

2007 Edition

Acid-Sensing Ion Channels

  • Nicolas Voilley
  • Michel Lazdunski
Reference work entry
DOI: https://doi.org/10.1007/978-3-540-29805-2_35

Synonyms

ASIC; ASIC1a; brain sodium channel 2 (BNC2, BNaC2); ASIC1b: ASICβ; ASIC2a: mammalian degenerin 1 (MDEG1), brain sodium channel 1 (BNC1, BNaC1); ASIC2b: mammalian degenerin 2 (MDEG2); ASIC3: dorsal-root acid-sensing ion channel (DRASIC)

Definition

Acid-Sensing Ion Channels (ASICs) are membrane protein complexes that form depolarizing ion channels present on peripheral and/or central neurons. These channels are opened by extracellular protons. Their activation induces action potential triggering on neurons after an extracellular pH decrease to acidic values. Such tissue  acidosis occurs during  inflammation or  ischemia, and is a major source of pain.

Characteristics

ASICs are membrane protein complexes formed by four subunits among the six characterized isoforms (Fig. 1). The isoforms are coded by four different genes, two of them spliced in two variants: ASIC1a and ASIC1b, ASIC2a and ASIC2b, ASIC3 and ASIC4 (Chen et al. 1998; Garcia-Anoveros et al. 1997; Grunder et al. 2000;...

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References

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  2. 2.
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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • Nicolas Voilley
    • 1
  • Michel Lazdunski
    • 1
  1. 1.Institut de Pharmacologie Moleculaire et CellulaireValbonneFrance