Encyclopedia of Pain

2007 Edition


Reference work entry
DOI: https://doi.org/10.1007/978-3-540-29805-2_34


Acidosis is the disturbance of the acid-base balance, characterized by acidity (decreased pH) by accumulation of protons, caused by injury, inflammation or ischemia. Acidosis is an important source of pain. In humans, it produces non-adapting nociceptor excitation and contributes to hyperalgesia and allodynia in inflammation.

 Acid-Sensing Ion Channels

 TRPV1, Regulation by Protons

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© Springer-Verlag Berlin Heidelberg 2007