Encyclopedia of Pain

2007 Edition

Autologous Thrombocyte Injection as a Model of Cutaneous Pain

  • James A. Blunk
  • Martin Schmelz
Reference work entry
DOI: https://doi.org/10.1007/978-3-540-29805-2_332


Blood Platelets; Intracutaneous Injection Pain; hyperalgesia; Cutaneous Pain Model


Thrombocytes are usually associated with the hemostasis or with vascular inflammatory processes. Little is known about the role of corpuscular components like white blood cells or platelets in the excitation and sensitization of nociceptors in human tissue. Injections of autologous preparations of human thrombocytes into the dermal layer of the skin are able to directly excite nociceptors and to induce an inflammatory  induration, showing prolonged primary mechanical and thermal hyperalgesia ( primary hyperalgesia). Neuronal and vascular reactions following platelet injections have been assessed by videography,  Laser-Doppler Flowmetry (LDF), and various other psychophysical methods to measure primary hyperalgesia. Injections of platelet preparations into the skin are intended to further increase the pathophysiological relevance of hyperalgesia models.



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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • James A. Blunk
    • 1
  • Martin Schmelz
    • 2
  1. 1.Clinic for AnaesthesiologyUniversity of ErlangenErlangenGermany
  2. 2.Faculty for Clinical Medicine in MannheimUniversity of HeidelbergMannheimGermany