Encyclopedia of Pain

2007 Edition

ATP-Dependent Na+/K+ Pump

Reference work entry
DOI: https://doi.org/10.1007/978-3-540-29805-2_312


The principal primary active transport system in neurons, the Na/K-ATPase utilizes energy to maintain cation cellular concentrations by extruding Na and accumulating K ions, thus creating an electrical potential across the neuronal cell membrane. It is estimated that 25 to 40% of brain energy utilization may be related to Na/K-ATPase activity. Abnormalities in the pump may lead to neuronal dysfunction, although the exact relationship to familial hemiplegic migraine is not known.

 Migraine, Childhood Syndromes

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© Springer-Verlag Berlin Heidelberg 2007