Encyclopedia of Pain

2007 Edition

Acetylation

Reference work entry
DOI: https://doi.org/10.1007/978-3-540-29805-2_30

Definition

The acetyl group of acetylsalicylic acid (aspirin) binds to serine 530 in the active site of COX–1, or serine 516 in the active site of COX–2. This prevents the access of arachidonic acid to the catalytic site of the cyclooxygenase.

 Cyclooxygenases in Biology and Disease

Copyright information

© Springer-Verlag Berlin Heidelberg 2007