Encyclopedia of Pain

2007 Edition

Articular Nociceptors

  • Hans-Georg Schaible
Reference work entry
DOI: https://doi.org/10.1007/978-3-540-29805-2_289


Joint nociceptors


 Articular nociceptors are primary afferent neurons in joint nerves (or primary afferent neurons supplying joints) that signal and encode the impact of noxious stimuli to joints. In the normal joint, articular nociceptors are mainly or exclusively activated by noxious mechanical stimuli applied to the joint. Articular nociceptors are sensitized for mechanical stimulation in the process of joint inflammation.


Pain in Joints

Pain in a normal joint is commonly elicited by twisting or hitting the joint. In conscious humans, pain in the normal joint can be elicited when noxious mechanical or chemical stimuli are applied to the fibrous structures, such as ligaments and fibrous capsule. No pain is elicited by stimulation of cartilage. Stimulation of normal synovial tissue rarely evokes pain. Stimulation of fibrous structures with innocuous mechanical stimulation can evoke pressure sensations.

Joint inflammation is characterized by...

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  1. 1.
    Dowd E, McQueen DS, Chessell IP, Humphrey PPA (1998a) P2X Receptor-Mediated Excitation of Nociceptive Afferents in the Normal and Arthritic Rat Knee Joint. Br J Pharmacol 125:341–346Google Scholar
  2. 2.
    Dowd E, McQueen DS, Chessell IP, Humphrey PPA (1998b) Adenosine A1 Receptor-Mediated Excitation of Nociceptive Afferents Innervating the Normal and Arthritic Rat Knee Joint. Br J Pharmacol 125:1267–1271Google Scholar
  3. 3.
    Guilbaud G, Iggo A, Tegner R (1985) Sensory Receptors in Ankle Joint Capsules of Normal and Arthritic Rats. Exp Brain Res 58:29–40Google Scholar
  4. 4.
    Heppelmann B, Messlinger K, Neiss W, Schmidt RF (1990) Ultrastructural Three-Dimensional Reconstruction of Group III and Group IV Sensory Nerve Endings (Free Nerve Endings) in the Knee Joint Capsule of the Rat: Evidence for Multiple Receptive Sites. J Comp Neurol 292:103–116Google Scholar
  5. 5.
    Heppelmann B, Just S, Pawlak M (2000) Galanin Influences the Mechanosensitivity of Sensory Endings in the Rat Knee Joint. Eur J Neurosci 12:1567–1572Google Scholar
  6. 6.
    Heppelmann B, Pawlak M (1997) Inhibitory Effect of Somatostatin on the Mechanosensitivity of Articular Afferents in Normal and Inflamed Knee Joints of the Rat. Pain 73:377–382Google Scholar
  7. 7.
    Herbert MK, Schmidt RF (2001) Sensitisation of Group III Articular Afferents to Mechanical Stimuli by Substance P. Inflamm Res 50:275–282Google Scholar
  8. 8.
    Just S, Heppelmann B (2001) Neuropeptide Y Changes the Excitability of Fine Afferent Units in the Rat Knee Joint. Br J Pharmacol 132:703–708Google Scholar
  9. 9.
    McDougall JJ, Pawlak M, Hanesch U, Schmidt RF (2000) Peripheral Modulation of Rat Knee Joint Afferent Mechanosensitivity by Nociceptin/Orphanin FQ. Neurosci Lett 288:123–126Google Scholar
  10. 10.
    Schaible H-G (2005) Basic Mechanisms of Deep Somatic Pain. In: McMahon SB, Koltzenburg M (eds) Textbook of Pain (in press)Google Scholar
  11. 11.
    Schaible H-G, Grubb BD (1993) Afferent and Spinal Mechanisms of Joint Pain. Pain 55:5–54Google Scholar
  12. 12.
    Schaible H-G, Schmidt RF (1983a) Activation of Groups III and IV Sensory Units in Medial Articular Nerve by Local Mechanical Stimulation of Knee Joint. J Neurophysiol 49:35–44Google Scholar
  13. 13.
    Schaible H-G, Schmidt RF (1983b) Responses of Fine Medial Articular Nerve Afferents to Passive Movements of Knee Joint. J Neurophysiol 49:1118–1126Google Scholar
  14. 14.
    Schaible H-G, Schmidt RF (1985) Effects of an Experimental Arthritis on the Sensory Properties of Fine Articular Afferent Units. J Neurophysiol 54:1109–1122Google Scholar
  15. 15.
    Schaible H-G, Schmidt RF (1988) Time Course of Mechanosensitivity Changes in Articular Afferents during a Developing Experimental Arthritis. J Neurophysiol 60:2180–2195Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • Hans-Georg Schaible
    • 1
  1. 1.Department of PhysiologyFriedrich-Schiller-University of JenaJenaGermany