Encyclopedia of Pain

2007 Edition

Articular Afferents, Morphology

  • Karl Messlinger
Reference work entry
DOI: https://doi.org/10.1007/978-3-540-29805-2_288


Articular Sensory Receptors; Sensory Endings in Joint Tissues


Afferent nerve fibers innervating articular tissues, in a narrow sense the sensory endings of afferent fibers in joint tissues, particularly in joint capsules and articular ligaments. Thick myelinated afferents form corpuscular nerve endings, thin myelinated and unmyelinated afferents are without a corpuscular end structure (non-corpuscular endings, free nerve endings).


Remarks on the Classification of Sensory Endings

Sensory receptors are either classified according to their morphological appearance, which is thought to be correlated with functional properties, or according to the electrophysiological properties of their sensory axons within peripheral nerves. The velocity of action potentials running along the afferent fiber is used for a basic classification, dividing the afferents into slowly conducting (Aδ or group III, and C or group IV) and fast conducting groups (Aβ or group II)....

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  1. 1.
    Andres KH, von Düring M. (1973) Morphology of Cutaneous Receptors. In: Iggo A (ed) Handbook of Sensory Physiology, vol 2, Somatosensory System. Springer, Berlin, pp 3–28Google Scholar
  2. 2.
    Ebinger M, Schmidt RF, Heppelmann B (2001) Composition of the Medial and Posterior Articular Nerves of the Mouse Knee Joint. Somatosens Mot Res 18:62–65Google Scholar
  3. 3.
    Freeman MAR, Wyke B (1967) The Innervation of the Knee Joint. An Anatomical and Histological Study in the Cat. J Anat 101:505–532Google Scholar
  4. 4.
    Halata Z, Rettig T, Schulze W (1985) The Ultrastructure of Sensory Nerve Endings in the Human Knee Joint Capsule. Anat Embryol 172:265–275Google Scholar
  5. 5.
    Hanesch U, Heppelmann B, Schmidt RF (1991) Substance P- and Calcitonin Gene-Related Peptide Immunoreactivity in Primary Afferent Neurons of the Cat’s Knee Joint. Neuroscience 45:185–193Google Scholar
  6. 6.
    Hanesch U, Heppelmann B, Schmidt RF (1995) Somatostatin-Like Immunoreactivity in Primary Afferents of the Medial Articular Nerve and Colocalization with Substance P in the Cat. J Comp Neurol 354:345–352Google Scholar
  7. 7.
    Hanesch U, Heppelmann B, Schmidt RF (1997) Quantification of Cat’s Articular Afferents Containing Calcitonin Gene-Related Peptide or Substance P Innervating Normal and Acutely Inflamed Knee Joint. Neurosci Lett 233:105–108Google Scholar
  8. 8.
    Heppelmann B (1997) Anatomy and Histology of Joint Innervation. J Peripher Nerv Syst 2:5–16Google Scholar
  9. 9.
    Heppelmann B, Heuss C, Schmidt RF (1988) Fiber Size Distribution of Myelinated and Unmyelinated Axons in the Medial and Posterior Articular Nerves of the Cat’s Knee Joint. Somatosens Res 5:273–281Google Scholar
  10. 10.
    Heppelmann B, Messlinger K, Neiss WF et al. (1990) Ultrastructural Three-Dimensional Reconstruction of Group III and Group IV Sensory Nerve Endings (“Free Nerve Endings") in the Knee Joint Capsule of the Cat: Evidence for Multiple Receptive Sites. J Comp Neurol 292:103–116Google Scholar
  11. 11.
    Heppelmann B, Messlinger K, Neiss WF et al. (1994) Mitochondria in Fine Afferent Nerve Fibres of the Knee Joint in the Cat: A Quantitative Electron-Microscopical Examination. Cell Tissue Res 275:493–501Google Scholar
  12. 12.
    Heppelmann B, Messlinger K, Neiss WF et al. (1995) Fine Sensory Innervation of the Knee Joint Capsule by Group III and Group IV Nerve Fibers in the Cat. J Comp Neurol 351:415–428Google Scholar
  13. 13.
    Hildebrandt C, Oqvist G, Brax L et al. (1991) Anatomy of the Rat Knee Joint and Fibre Composition of a Major Articular Nerve. Anat Rec 229:545–555Google Scholar
  14. 14.
    Hinsey JC (1927) Some Observations on the Innervation of Skeletal Muscle of the Cat. J Comp Neurol 44:87–195Google Scholar
  15. 15.
    Langford LA, Schmidt RF (1983) Afferent and Efferent Axons in the Medial and Posterior Articular Nerves of the Cat. Anat Rec 206:71–78Google Scholar
  16. 16.
    Messlinger K, Pawlak M, Steinbach H et al. (1995) A New Combination of Methods for Localization, Identification, and Three-Dimensional Reconstruction of the Sensory Endings of Articular Afferents Characterized by Electrophysiology. Cell Tissue Res 281: 283–294Google Scholar
  17. 17.
    Messlinger K (1996) Functional Morphology of Nociceptive and other Fine Sensory Endings (“Free Nerve Endings") in Different Tissues. In: Kumazawa T, Kruger L, Mizumura K (eds) The Polymodal Receptor – a Gateway to Pathological Pain – Progress in Brain Research, vol 113. Elsevier, Amsterdam, pp 273–298Google Scholar
  18. 18.
    Salo PT, Theriault E (1997) Number, Distribution and Neuropeptide Content of Rat Knee Joint Afferents. J Anat 190:515–522Google Scholar
  19. 19.
    Tamura R, Hanesch U, Schmidt RF et al. (1998) Examination of Colocalization of Calcitonin Gene-Related Peptide- and Substance P-Like Immunoreactivity in the Knee Joint of the Dog. Neurosci Lett 254:53–56Google Scholar
  20. 20.
    Weddell G, Harpman JA (1940) The Neurohistological Basis for the Sensation of Pain Provoked from Deep Fascia, Tendon, and Periosteum. J Neurol Neurosurg Psychiat 3:319–328Google Scholar
  21. 21.
    Zimny ML (1988) Mechanoreceptors in Articular Tissues. Am J Anat 182:16–32Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • Karl Messlinger
    • 1
  1. 1.University of Erlangen-NürnbergErlangenGermany