Encyclopedia of Pain

2007 Edition

Arthritis Model, Osteoarthritis

  • James D. Pomonis
Reference work entry
DOI: https://doi.org/10.1007/978-3-540-29805-2_284

Synonyms

Degenerative Joint Disease; Arthritis; Osteoarthritis Model

Definition

Osteoarthritis is a condition in which physical or biological damage to the cartilage of  synovial joints leads to destruction of the  cartilage and remodeling of the bone underneath the affected cartilage.

Characteristics

Osteoarthritis (OA) and other degenerative joint diseases affect almost one third of all adults, equaling nearly 70 million adults in the United States and 34 million adults in Europe. It is the leading cause of disability in the United States. The most important risk factor for OA is age (Elders 2000), and as the aging population is dramatically increasing, the prevalence of the disease is likewise expected to increase. OA is distinct from rheumatoid arthritis, which is a systemic inflammatory disease, and is much less prevalent.

OA is frequently associated with severe pain, but the sources of this pain are not fully understood, which has presented many obstacles for its treatment and...

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References

  1. 1.
    Altma R, Hochberg M, Moskowitcz RW, Schnitzer TJ (2000) Recommendations for the Medical Management of Osteoarthritis of the Hip and Knee: 2000 Update. Arthritis and Rheumatism 43:1905–1915Google Scholar
  2. 2.
    Bove S, Calcaterra S et al. (2003) Weight Bearing as a Measure of Disease Progression and Efficacy of Anti-Inflammatory Compounds in a Model of Monosodium Iodoacetate-Induced Osteoarthritis. Osteoarthritis and Cartilage 11:821–830Google Scholar
  3. 3.
    Cushnaghan J, Cooper C et al. (1990) Clinical Assessment of Osteoarthritis of the Knee. Annals of the Rheumatic Diseases 49:768–770Google Scholar
  4. 4.
    Elders MJ (2000) The Increasing Impact of Arthritis on Public Health. J Rheumatol 60:6–8Google Scholar
  5. 5.
    Fernihough J, Gentry C et al. (2004) Pain Related Behaviour in Two Models of Osteoarthritis in the Rat Knee. Pain 112:83–93Google Scholar
  6. 6.
    Guingamp C, Gefout-Pottie P et al. (1997) Mono-Iodoacetate-Induced Experimental Osteoarthritis: A Dose-Response Study of Loss of Mobility, Morphology, and Biochemistry. Arthritis and Rheumatism 40:1670–1679Google Scholar
  7. 7.
    Guzman R, Evans M et al. (2003) Mono-Iodoacetate-Induced Histologic Changes in Subchondral Bone and Articular Cartilage of Rat Femorotibial Joints: An Animal Model of Osteoarthritis. Toxicologic Pathology 31:619–624Google Scholar
  8. 8.
    Kobayashi K, Imaizumi R et al. (2003) Sodium Iodoacetate-Induced Experimental Osteoarthritis and Associated Pain Model in Rats. J Vet Med Sci 65(11):1195–1199Google Scholar
  9. 9.
    Pomonis JD, Boulet J et al. (2005) Development and Pharmacological Characterization of a Rat Model of Osteoarthritis Pain. Pain: 114:339–346Google Scholar
  10. 10.
    Scheiman JM (2003) Gastroduodenal Safety of Cyclooxygenase-2 Inhibitors. Current Pharmaceutical Design 9:2197–206Google Scholar
  11. 11.
    van der Kraan P, Vitters E et al. (1989) Development of Osteoarthritic Lesions in Mice by “Metabolic” and “Mechanical” Alterations in the Knee Joints. Am J Pathol 135:1001–1014Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • James D. Pomonis
    • 1
  1. 1.Algos Therapeutics Inc.St. PaulMNUSA