Encyclopedia of Pain

2007 Edition

Arthritis Model, Osteoarthritis

  • James D. Pomonis
Reference work entry
DOI: https://doi.org/10.1007/978-3-540-29805-2_284


Degenerative Joint Disease; Arthritis; Osteoarthritis Model


Osteoarthritis is a condition in which physical or biological damage to the cartilage of  synovial joints leads to destruction of the  cartilage and remodeling of the bone underneath the affected cartilage.


Osteoarthritis (OA) and other degenerative joint diseases affect almost one third of all adults, equaling nearly 70 million adults in the United States and 34 million adults in Europe. It is the leading cause of disability in the United States. The most important risk factor for OA is age (Elders 2000), and as the aging population is dramatically increasing, the prevalence of the disease is likewise expected to increase. OA is distinct from rheumatoid arthritis, which is a systemic inflammatory disease, and is much less prevalent.

OA is frequently associated with severe pain, but the sources of this pain are not fully understood, which has presented many obstacles for its treatment and...

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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • James D. Pomonis
    • 1
  1. 1.Algos Therapeutics Inc.St. PaulMNUSA