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Arthritis Model, Kaolin-Carrageenan Induced Arthritis (Knee)

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Encyclopedia of Pain

Synonyms

Kaolin-Carrageenan induced arthritis; K/C Arthritis; Acute Experimental Monoarthritis; Acute Knee Joint Inflammation; Acute Experimental Synovitis

Definition

Aseptic inflammatory monoarthritis induced by injections of kaolin and carrageenan into the synovial cavity of one knee joint, resulting in damage to the cartilage, inflammation of the synovia and synovial fluid exudates, as well as pain behavior and neuroplastic changes in the peripheral and central nervous system.

Characteristics

The K/C arthritis is a well established model of an acute onset monoarthritis resembling osteoarthritis, which is characterized by degeneration of hyaline articular cartilage and subsequent inflammation and pain. The K/C arthritis model has been used in cats (Coggeshall et al. 1983; Schaible and Grubb 1993), monkeys (Dougherty et al. 1992), rats (Neugebauer et al. 1993; Sluka and Westlund 1993) and mice (Zhang et al. 2001) to study pain mechanisms in the peripheral and central nervous system....

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References

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Author information

Authors and Affiliations

  1. Department of Neurosciences & Cell Biology, University of Texas Medical Branch, Galveston, TX, USA

    Volker Neugebauer

Authors
  1. Volker Neugebauer
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Editor information

Editors and Affiliations

  1. Physiological Institute, University of Würzburg, Würzburg, Germany

    Robert F. Schmidt

  2. Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas, USA

    William D. Willis

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© 2007 Springer-Verlag Berlin Heidelberg

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Neugebauer, V. (2007). Arthritis Model, Kaolin-Carrageenan Induced Arthritis (Knee). In: Schmidt, R., Willis, W. (eds) Encyclopedia of Pain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29805-2_283

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  • DOI: https://doi.org/10.1007/978-3-540-29805-2_283

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-43957-8

  • Online ISBN: 978-3-540-29805-2

  • eBook Packages: MedicineReference Module Medicine

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