Encyclopedia of Pain

2007 Edition

Arthritis Model, Kaolin-Carrageenan Induced Arthritis (Knee)

  • Volker Neugebauer
Reference work entry
DOI: https://doi.org/10.1007/978-3-540-29805-2_283


Kaolin-Carrageenan induced arthritis; K/C Arthritis; Acute Experimental Monoarthritis; Acute Knee Joint Inflammation; Acute Experimental Synovitis


Aseptic inflammatory monoarthritis induced by injections of kaolin and carrageenan into the synovial cavity of one knee joint, resulting in damage to the cartilage, inflammation of the synovia and synovial fluid exudates, as well as pain behavior and neuroplastic changes in the peripheral and central nervous system.


The K/C arthritis is a well established model of an acute onset monoarthritis resembling osteoarthritis, which is characterized by degeneration of hyaline articular cartilage and subsequent inflammation and pain. The K/C arthritis model has been used in cats (Coggeshall et al. 1983; Schaible and Grubb 1993), monkeys (Dougherty et al. 1992), rats (Neugebauer et al. 1993; Sluka and Westlund 1993) and mice (Zhang et al. 2001) to study pain mechanisms in the peripheral and central nervous system....

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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • Volker Neugebauer
    • 1
  1. 1.Department of Neurosciences & Cell BiologyUniversity of Texas Medical BranchGalvestonUSA