Encyclopedia of Pain

2007 Edition

Arthritis Model, Kaolin-Carrageenan Induced Arthritis (Knee)

  • Volker Neugebauer
Reference work entry
DOI: https://doi.org/10.1007/978-3-540-29805-2_283

Synonyms

Kaolin-Carrageenan induced arthritis; K/C Arthritis; Acute Experimental Monoarthritis; Acute Knee Joint Inflammation; Acute Experimental Synovitis

Definition

Aseptic inflammatory monoarthritis induced by injections of kaolin and carrageenan into the synovial cavity of one knee joint, resulting in damage to the cartilage, inflammation of the synovia and synovial fluid exudates, as well as pain behavior and neuroplastic changes in the peripheral and central nervous system.

Characteristics

The K/C arthritis is a well established model of an acute onset monoarthritis resembling osteoarthritis, which is characterized by degeneration of hyaline articular cartilage and subsequent inflammation and pain. The K/C arthritis model has been used in cats (Coggeshall et al. 1983; Schaible and Grubb 1993), monkeys (Dougherty et al. 1992), rats (Neugebauer et al. 1993; Sluka and Westlund 1993) and mice (Zhang et al. 2001) to study pain mechanisms in the peripheral and central nervous system....

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References

  1. 1.
    Coggeshall RE, Hong KA, Langford LA et al. (1983) Discharge Characteristics of Fine Medial Articular Afferents at Rest and during Passive Movements of Inflamed Knee Joints. Brain Res 272:185–188Google Scholar
  2. 2.
    Dougherty PM, Sluka KA, Sorkin LS et al. (1992) Neural Changes in Acute Arthritis in Monkeys. I. Parallel Enhancement of Responses of Spinothalamic Tract Neurons to Mechanical Stimulation and Excitatory Amino Acids. Brain Res Rev 55:1–13Google Scholar
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    Lawand NB, McNearney T, Westlund KN (2000) Amino Acid Release into the Knee Joint: Key Role in Nociception and Inflammation. Pain 86:69–74Google Scholar
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    Neugebauer V, Li W (2003) Differential Sensitization of Amygdala Neurons to Afferent Inputs in a Model of Arthritic Pain. J Neurophysiol 89:716–727Google Scholar
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    Neugebauer V, Li W, Bird GC et al. (2003) Synaptic Plasticity in the Amygdala in a Model of Arthritic Pain: Differential Roles of Metabotropic Glutamate Receptors 1 and 5. J Neurosci 23:52–63Google Scholar
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    Neugebauer V, Lucke T, Schaible H-G (1993) N-methyl-D-aspartate (NMDA) and Non-NMDA Receptor Antagonists Block the Hyperexcitability of Dorsal Horn Neurons during Development of Acute Arthritis in Rat's Knee Joint. J Neurophysiol 70:1365–1377Google Scholar
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    Sluka KA (1996) Pain Mechanisms Involved in Musculoskeletal Disorders. J Orthop Sports Phys Ther 24:240–254Google Scholar
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    Sluka KA, Rees H, Westlund KN et al. (1995) Fiber Types Contributing to Dorsal Root Reflexes Induced by Joint Inflammation in Cats and Monkeys. J Neurophysiol 74:981–989Google Scholar
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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • Volker Neugebauer
    • 1
  1. 1.Department of Neurosciences & Cell BiologyUniversity of Texas Medical BranchGalvestonUSA