Encyclopedia of Pain

2007 Edition

Arthritis Model, Adjuvant-Induced Arthritis

  • Lucy F. Donaldson
  • Naomi L. Chillingworth
Reference work entry
DOI: https://doi.org/10.1007/978-3-540-29805-2_282


Adjuvant Arthritis; adjuvant-induced arthritis


Adjuvant-induced  arthritis is a model of chronic immune-mediated joint inflammation that is induced by injection, usually sub– or intradermally, of a suspension of heat killed Mycobacterium tuberculosis ( Mycobacterium Species) in oil ( Freund's complete adjuvant or FCA).


The classical model of adjuvant induced polyarthritis is induced in rats, using an intradermal injection of mycobacterium tuberculosis suspension in paraffin oil at the tail base. The reaction to adjuvant injection is generally one of systemic illness, with inflammation affecting tarsal, carpal, phalangeal and spinal joints after 11–16 days (Pearson and Wood 1959). Arthritis is accompanied by lesions of the eyes, ears, nose, skin and genitals, in addition to anorexia and profound weight loss. The disease follows a relapsing-remitting course after the initial two weeks and may persist for several months (Pearson and Wood 1959).


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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • Lucy F. Donaldson
    • 1
  • Naomi L. Chillingworth
    • 1
  1. 1.Department of PhysiologySchool of Medical SciencesUniversity of BristolUK