Encyclopedia of Pain

2007 Edition

Arthritis Model, Adjuvant-Induced Arthritis

  • Lucy F. Donaldson
  • Naomi L. Chillingworth
Reference work entry
DOI: https://doi.org/10.1007/978-3-540-29805-2_282

Synonyms

Adjuvant Arthritis; adjuvant-induced arthritis

Definition

Adjuvant-induced  arthritis is a model of chronic immune-mediated joint inflammation that is induced by injection, usually sub– or intradermally, of a suspension of heat killed Mycobacterium tuberculosis ( Mycobacterium Species) in oil ( Freund's complete adjuvant or FCA).

Characteristics

The classical model of adjuvant induced polyarthritis is induced in rats, using an intradermal injection of mycobacterium tuberculosis suspension in paraffin oil at the tail base. The reaction to adjuvant injection is generally one of systemic illness, with inflammation affecting tarsal, carpal, phalangeal and spinal joints after 11–16 days (Pearson and Wood 1959). Arthritis is accompanied by lesions of the eyes, ears, nose, skin and genitals, in addition to anorexia and profound weight loss. The disease follows a relapsing-remitting course after the initial two weeks and may persist for several months (Pearson and Wood 1959).

The...

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References

  1. 1.
    Audibert F, Chedid L (1976) Adjuvant Disease Induced by Mycobacteria, Determinants of Arthritogenicity. Agents Actions 6:75–85Google Scholar
  2. 2.
    Butler SH, Godefroy F, Besson JM, Weil-Fugazza J (1992) A Limited Arthritic Model for Chronic Pain Studies in the Rat. Pain 48:73–81Google Scholar
  3. 3.
    Chillingworth NL, Donaldson LF (2003) Characterisation of a Freund's Complete Adjuvant-Induced Model of Chronic Arthritis in Mice. J Neurosci Meth 128:45-52Google Scholar
  4. 4.
    Colpaert FC, Meert T, De Witte P, Schmitt P (1982) Further Evidence Validating Adjuvant Arthritis as an Experimental Model of Chronic Pain in the Rat. Life Sci 31:67–75Google Scholar
  5. 5.
    De Castro Costa M, De Sutter P, Gybels J, Van Hees J (1981) Adjuvant-Induced Arthritis in Rats: A Possible Animal Model of Chronic Pain. Pain 10:73–185Google Scholar
  6. 6.
    Decaris E, Guingamp C, Chat M, Philippe L, Grillasca JP, Abid A, Minn A, Gillet P, Netter P, Terlain B (1999) Evidence for Neurogenic Transmission Inducing Degenerative Cartilage Damage Distant from Local Inflammation. Arthritis Rheum 42:1951–1960Google Scholar
  7. 7.
    Donaldson LF, McQueen DS, Seckl JR (1994) Endogenous Glucocorticoids and the Induction and Spread of Monoarthritis in the Rat. J Neuroendocrinol 6:649–654Google Scholar
  8. 8.
    Donaldson LF, McQueen DS, Seckl JR (1995) Neuropeptide Gene Expression and Capsaicin-Sensitive Primary Afferents: Maintenance and Spread of Adjuvant Arthritis in the Rat. J Physiol 486:473–482Google Scholar
  9. 9.
    Donaldson LF, Seckl JR, McQueen DS (1993) A Discrete Adjuvant-Induced Monoarthritis in the Rat: Effects of Adjuvant Dose. J Neurosci Methods 49:5–10Google Scholar
  10. 10.
    Gauldie SD, McQueen DS, Clarke CJ, Chessell IP (2004) A robust model of adjuvant-induced chronic unilateral arthritis in two mouse strains. J Neurosci Meth 139(2):281-29Google Scholar
  11. 11.
    Hood VC, Cruwys SC, Urban L, Kidd BL (2001) The Neurogenic Contribution to Synovial Leucocyte Infiltration and Other Outcome Measures in a Guinea Pig Model of Arthritis. Neurosci Lett 299:201–204Google Scholar
  12. 12.
    Larson AA, Brown DR, el-Atrash S, Walser MM (1986) Pain Threshold Changes in Adjuvant-Induced Inflammation: A Possible Model of Chronic Pain in the Mouse. Pharmacol Biochem Behav 24:49–53Google Scholar
  13. 13.
    Pearson CM, Wood FD (1959) Studies of Polyarthritis and Other Lesions in Rats by Injection of Mycobacterial Adjuvant. I. General Clinical and Pathological Characteristics and some Modifying Factors. Arthritis Rheum 2:440–45Google Scholar
  14. 14.
    Pettipher ER, Henderson B (1988) The Relationship between Cell-Mediated Immunity and Cartilage Degradation in Antigen-Induced Arthritis in the Rabbit. Br J Exp Pathol 69:113–122Google Scholar
  15. 15.
    Rainsford KD (1982) Adjuvant Polyarthritis in Rats: Is this a Satisfactory Model for Screening Anti-Arthritic Drugs? Agents Actions 12:452–458.Google Scholar
  16. 16.
    Ratkay LG, Tait B, Tonzetich J, Waterfield JD (1994) Lpr and MRL Background Gene Involvement in the Control of Adjuvant Enhanced Arthritis in MRL-lpr Mice. J Autoimmun 7:561–573Google Scholar
  17. 17.
    Sarlis NJ, Chowdrey HS, Stephanou A, Lightman SL (1992) Chronic Activation of the Hypothalamo-Pituitary-Adrenal Axis and Loss of Circadian Rhythm During Adjuvant-Induced Arthritis in the Rat. Endocrinology 130:1775–1779Google Scholar
  18. 18.
    van Eden W, Holoshitz J, Nevo Z, Frenkel A, Klajman A, Cohen IR (1985) Arthritis Induced by a T-Lymphocyte Clone that Responds to Mycobacterium Tuberculosis and to Cartilage Proteoglycans. Proc Natl Acad Sci USA 82:511701–5120Google Scholar
  19. 19.
    Wakesman BH, Pearson CM, Sharp JT (1960) Studies of Arthritis and other Lesions Induced in Rats by Injection of Mycobacterial Adjuvant. II. Evidence that the Disease is a Disseminated Immunologic Response to Exogenous Antigen. Proc Natl Acad Sci USA 85:403–417Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • Lucy F. Donaldson
    • 1
  • Naomi L. Chillingworth
    • 1
  1. 1.Department of PhysiologySchool of Medical SciencesUniversity of BristolUK