Encyclopedia of Pain

2007 Edition

Antisense Oligonucleotide

Reference work entry
DOI: https://doi.org/10.1007/978-3-540-29805-2_261




A DNA sequence, typically 15 to 25 nucleotides in length, designed to bind to a complementary sequence on a target RNA molecule. As a result, the protein product coded by that particular RNA is not synthesized. ASO can be delivered in vitro or in vivo to reversibly inhibit the synthesis of a protein of interest.

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© Springer-Verlag Berlin Heidelberg 2007