Encyclopedia of Pain

2007 Edition

Antinociceptive Models

Reference work entry
DOI: https://doi.org/10.1007/978-3-540-29805-2_258


Animal models of experimental pain include the tail flick test,  Hot Plate Test (Assay), warm water tail withdrawal, abdominal constriction, paw pressure and others. In all cases, a measured nociceptive stimulus of a thermal, chemical or pressure nature is applied and the response of the animal is monitored. For instance, thermal stimuli typically produce a pre-determined response within a latency time; antinociception is determined by the prolongation of the latency time. A chemical stimulus such as phenylquinone or acetic acid typically induces abdominal constrictions, which can be suppressed by analgesic drugs.

 Nitrous Oxide Antinociception and Opioid Receptors

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© Springer-Verlag Berlin Heidelberg 2007