Encyclopedia of Pain

2007 Edition

Animal Models of Inflammatory Bowel Disease

  • Julie A. Christianson
  • Brian Davis
Reference work entry
DOI: https://doi.org/10.1007/978-3-540-29805-2_227


Colitis; Crohn’s Disease; Inflammatory Bowel Disease, Animal Models; Ulcerative Colitis


Inflammatory bowel disease (IBD) manifests as a complex chronic inflammatory disorder thought to be caused by a combination of environmental and genetic factors. Clinically, IBD presents as either ulcerative colitis (UC) or Crohn’s disease (CD), which predominantly affect the colon and/or the distal small intestine, respectively (Hendrickson et al. 2002).


Approximately 600,000 Americans suffer from IBD, with the majority of patients diagnosed with the disease during their third decade of life. The most common symptoms include diarrhea, abdominal pain, fever, weight loss,  arthralgiasand arthritis (Hendrickson et al. 2002). While the exact causes of IBD remain unknown, certain environmental and genetic factors have been shown to play a role in the development of IBD. Environmental factors may include smoking, diet, physical activity, childhood infections,...

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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • Julie A. Christianson
    • 1
  • Brian Davis
    • 1
  1. 1.University of PittsburghPittsburghPAUSA