Introduction
Animal models and experimental tests are the fundamental tools that make studying nociception and pain possible. In fact, it would not be an exaggeration to say that progress in pain research has been made only to the degree that these essential research tools are available.
Perhaps, the oldest and the most commonly used nociceptive test would be the tail flick testthat was developed by D'Amour and Smith in 1941 (D'Amour and Smith 1941). Following this early test, which is a test for acute pain in normal rodents, many other tests and models for chronic or persistent pain using various animals have been developed. The availability of these new tests and models has made it possible for research on persistent pain to flourish during the last decade. The present section attempts to document the majority of commonly used animal models and experimental tests. Hence, this section would be a good reference source for those who want to know about these basic tools for pain...
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References
Bennett GJ, Xie Y-K (1988) A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 33:87–107
D'Amour FE, Smith DL (1941) A method for determining loss of pain sensation. J Pharmacol Exp Ther 72:74–79
Decosterd I, Woolf CJ (2000) Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain 87:149–158
Hargreaves K, Dubner R, Brown F et al. (1988) A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32:77–88
Kim SH, Chung JM (1991) Sympathectomy alleviates mechanical allodynia in an experimental animal model for neuropathy in the rat. Neurosci Lett 134:131–134
Kim SH, Chung JM (1992) An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat. Pain 50:355–363
Kim KJ, Yoon YW, Chung JM (1997) Comparison of three rodent neuropathic pain models. Exp Brain Res 113:200–206
Mitchell SW (1872) Injuries of nerves and their consequences. JB Lippincott, Philadelphia, pp 252–281
Na HS, Han JS, Ko KH et al. (1994) A behavioral model for peripheral neuropathy produced in rat's tail by inferior caudal trunk injury. Neurosci Lett 177:50–52
Seltzer Z, Dubner R, Shir Y (1990) A novel behavioral model of neuropathic pain disorders produced in rats by partial sciatic nerve injury. Pain 43:205–218
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© 2007 Springer-Verlag Berlin Heidelberg
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Chung, J. (2007). Animal Models and Experimental Tests to Study Nociception and Pain. In: Schmidt, R., Willis, W. (eds) Encyclopedia of Pain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29805-2_225
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DOI: https://doi.org/10.1007/978-3-540-29805-2_225
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