Encyclopedia of Pain

2007 Edition

Animal Models and Experimental Tests to Study Nociception and Pain

  • Jin Mo Chung
Reference work entry
DOI: https://doi.org/10.1007/978-3-540-29805-2_225


Animal models and experimental tests are the fundamental tools that make studying nociception and pain possible. In fact, it would not be an exaggeration to say that progress in pain research has been made only to the degree that these essential research tools are available.

Perhaps, the oldest and the most commonly used nociceptive test would be the  tail flick testthat was developed by D'Amour and Smith in 1941 (D'Amour and Smith 1941). Following this early test, which is a test for acute pain in normal rodents, many other tests and models for chronic or persistent pain using various animals have been developed. The availability of these new tests and models has made it possible for research on persistent pain to flourish during the last decade. The present section attempts to document the majority of commonly used animal models and experimental tests. Hence, this section would be a good reference source for those who want to know about these basic tools for pain...

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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • Jin Mo Chung
    • 1
  1. 1.Department of Neuroscience and Cell BiologyUniversity of Texas Medical BranchGalvestonUSA