Synonyms
Visceral Sensation; interoceptive sensation; Sympathetic Afferents
Definition
The role of the somatic sensory thalamus in angina related to cardiac disease is demonstrated by stimulation of thalamus in patients with a history of angina and by the presence of cells projecting to monkey thalamus that respond to cardiac stimulation.
Characteristics
The sensory mechanisms of angina are poorly understood, although it is a common, clinically significant symptom. Recent evidence suggests that the perception of angina is correlated with central nervous system activity encoding cardiac injury. Noxious cardiac stimuli evoke activity in sympathetic afferent nerves (Foreman et al. 1986), in ascending spinal pathways (spinothalamic - STT and dorsal column pathways DC) and in cells of the principal sensory nucleus of the thalamus (Horie and Yokota 1990).
STT cells in the upper thoracic spinal cord projecting to the region of VPrespond to coronary artery occlusion (Blair et al. 1984) and...
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Apkarian AV, Hodge CJ (1989) Primate spinothalamic pathways: III. Thalamic terminations of the dorsolateral and ventral spinothalamic pathways. J Comp Neurol 288:493–511
Berthier M, Starkstein S, Leiguarda R (1988) Asymbolia for pain: a sensory-limbic disconnection syndrome. Ann Neurol 24:41–49
Blair RW, Weber N, Foreman RD (1982) Responses of thoracic spinothalamic neurons to intracardiac injection of bradykinin in the monkey. Circ Res 51:83–94
Blair RW, Ammons WS, Foreman RD (1984) Responses of thoracic spinothalamic and spinoreticular cells to coronary artery occlusion. J Neurophysiol 51:636–648
Bruggemann J, Shi T, Apkarian AV (1998) Viscerosomatic interactions in the thalamic ventral posterolateral nucleus (VPL) of the squirrel monkey. Brain Res 787:269–276
Chatrian GE, Canfield RC, Knauss TA et al. (1975) Cerebral responses to electrical tooth pulp stimulation in man. An objective correlate of acute experimental pain. Neurology 25:745–757
Dong WK, Salonen LD, Kawakami Y et al. (1989) Nociceptive responses of trigeminal neurons in SII-7b cortex of awake monkeys. Brain Res 484:314–324
Foreman RD, Blair RW, Ammons WS (1986) Neural mechanisms of cardiac pain. In: Cervero F, Morrison JFB (eds) Progress in Brain Research. Elsevier Science Publishers BV, New York, Amsterdam, Oxford, pp 227–243
Friedman DP, Murray EA, O'Neill JB et al. (1986) Cortical connections of the somatosensory fields of the lateral sulcus of macaques: evidence for a corticolimbic pathway for touch. J Comp Neurol 252:323–347
Greenspan JD, Winfield JA (1992) Reversible pain and tactile deficits associated with a cerebral tumor compressing the posterior insula and parietal operculum. Pain 50:29–39
Halgren E, Walter RD, Cherlow DG et al. (1978) Mental phenomena evoked by electrical stimulation of the human hippocampal formation and amygdala. Brain 101:83–117
Horie H, Yokota T (1990) Responses of nociceptive VPL neurons to intracardiac injection of bradykinin in the cat. Brain Res 516:161–164
Jones EG (1985) The Thalamus. Plenum, New York
Lenz FA, Seike M, Richardson RT et al. (1993) Thermal and pain sensations evoked by microstimulation in the area of human ventrocaudal nucleus. J Neurophysiol 70:200–212
Lenz FA, Gracely RH, Hope EJ et al. (1994) The sensation of angina can be evoked by stimulation of the human thalamus. Pain 59:119–125
Lenz FA, Gracely RH, Romanoski AJ et al. (1995) Stimulation in the human somatosensory thalamus can reproduce both the affective and sensory dimensions of previously experienced pain. Nat Med 1:910–913
Locke S, Angevine JB, Marin OSM (1961) Projection of magnocellular medial geniculate nucleus in man. Anat.Rec 139:249–250
Mehler WR (1962) The anatomy of the so-called “pain tract” in man: an analysis of the course and distribution of the ascending fibers of the fasciculus anterolateralis. In: French JD, Porter RW (eds) Basic Research in Paraplegia. Thomas, Springfield, pp 26–55
Meller ST, Gebhart GF (1992) A critical review of the afferent pathways and the potential chemical mediators involved in cardiac pain. Neurosci 48:501–524
Mishkin M (1979) Analogous neural models for tactual and visual learning. Neuropsych 17:139–151
Taguchi H, Masuda T, Yokota T (1987) Cardiac sympathetic afferent input onto neurons in nucleus ventralis posterolateralis in cat thalamus. Brain Res 436:240–252
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2007 Springer-Verlag Berlin Heidelberg
About this entry
Cite this entry
Anderson, S., Ohara, S., Weiss, N., Lenz, F. (2007). Angina Pectoris, Neurophysiology and Psychophysics. In: Schmidt, R., Willis, W. (eds) Encyclopedia of Pain. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-29805-2_222
Download citation
DOI: https://doi.org/10.1007/978-3-540-29805-2_222
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-43957-8
Online ISBN: 978-3-540-29805-2
eBook Packages: MedicineReference Module Medicine