Encyclopedia of Pain

2007 Edition

Angina Pectoris, Neurophysiology and Psychophysics

  • Stan Anderson
  • Shinji Ohara
  • Nirit Weiss
  • Fred A. Lenz
Reference work entry
DOI: https://doi.org/10.1007/978-3-540-29805-2_222


Visceral Sensation; interoceptive sensation; Sympathetic Afferents


The role of the somatic sensory  thalamus in angina related to cardiac disease is demonstrated by stimulation of thalamus in patients with a history of angina and by the presence of cells projecting to monkey thalamus that respond to cardiac stimulation.


The sensory mechanisms of angina are poorly understood, although it is a common, clinically significant symptom. Recent evidence suggests that the perception of angina is correlated with central nervous system activity encoding cardiac injury. Noxious cardiac stimuli evoke activity in sympathetic afferent nerves (Foreman et al. 1986), in ascending spinal pathways (spinothalamic -  STT and  dorsal column pathways DC) and in cells of the principal sensory nucleus of the  thalamus (Horie and Yokota 1990).

STT cells in the upper thoracic spinal cord projecting to the region of  VPrespond to coronary artery occlusion (Blair et al. 1984)...

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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • Stan Anderson
    • 1
  • Shinji Ohara
    • 1
  • Nirit Weiss
    • 1
  • Fred A. Lenz
    • 1
  1. 1.Departments of NeurosurgeryJohns Hopkins UniversityBaltimoreUSA