Encyclopedia of Pain

2007 Edition

Alpha(α)-D Galactose

Reference work entry
DOI: https://doi.org/10.1007/978-3-540-29805-2_169


Lectins are proteins that bind to the carbohydrate portion of glycoproteins and glycolipids. The isolectin Griffonia simplicifolia I–B4 (IB4) binds specifically to terminal α-galactose, the terminal sugar on galactose-α1,3-galactose carbohydrates on glycoproteins and glycolipids. The IB4 lectin labels about one half of the small- and medium-diameter DRG neurons in rat and mouse. It is not yet clear which proteins or lipids in DRG neurons account for the majority of labeling by IB4 binding.

 Immunocytochemistry of Nociceptors

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© Springer-Verlag Berlin Heidelberg 2007