Encyclopedia of Pain

2007 Edition

Alpha(α) 2-Adrenoceptors

Reference work entry
DOI: https://doi.org/10.1007/978-3-540-29805-2_164


α2-Adrenoceptors are G protein coupled receptors, which inhibit accumulation of cyclic adenosine monophosphate (cAMP), inhibit N-type and P/Q-type calcium channels, and activate potassium channels and Na+/H+ antiporter. Three receptor subtypes have so far been identified: α2A, α2B and α2C.

 Alpha (α) 2-Adrenergic Agonists in Pain Treatment

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© Springer-Verlag Berlin Heidelberg 2007