Encyclopedia of Pain

2007 Edition

Allodynia Test, Mechanical and Cold Allodynia

  • Kyungsoon Chung
Reference work entry
DOI: https://doi.org/10.1007/978-3-540-29805-2_156

Synonym

Mechanical Allodynia Test; cold allodynia test

Definition

Allodynia is defined as “pain due to a stimulus which does not normally provoke pain” by the International Association for the Study of Pain (Lindblom et al. 1986). It is important to recognize that allodynia involves a change in the quality of a sensation, since the original modality is normally non-painful but the response is painful. There is, thus, a loss of specificity of a sensory modality.

Characteristics

Because allodynia is an evoked pain, testing requires an external stimulation of non-painful quality. Two different types of stimulation have been used to test allodynia in animal models of neuropathic pain: mechanical and cold. All testing methods rely on foot withdrawal response to stimulus, based on the premise that the animal’s avoidance of touching or cooling is an allodynic reaction.

Mechanical Allodynia Test: Foot Withdrawal Response to Von Frey Filament Stimulus

Since mechanical allodynia is a major...

This is a preview of subscription content, log in to check access.

References

  1. 1.
    Baik EJ, Chung JM, Chung K (2003) Peripheral Norepinephrine Exacerbates Neuritis-Induced Hyperalgesia. J Pain 4:212–221Google Scholar
  2. 2.
    Bennett GJ (1999) Does a Neuroimmune Interaction Contribute to the Genesis of Painful Peripheral Neuropathies? Proc Natl Acad Sci USA 96:7737–7738Google Scholar
  3. 3.
    Bennett GJ, Xie Y-K (1988) A Peripheral Mononeuropathy in Rat that Produces Disorders of Pain Sensation like those Seen in Man. Pain 33:87–107Google Scholar
  4. 4.
    Bonica JJ (1990) Causalgia and Other Reflex Sympathetic Dystrophies. In: Bonica JJ (ed) The Management of Pain. Lea & Febiger, Philadelphia, pp 220–243Google Scholar
  5. 5.
    Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL (1994) Quantitative Assessment of Tactile Allodynia in the Rat Paw. J Neurosci Methods 53:55–63Google Scholar
  6. 6.
    Choi Y, Yoon YW, Na HS, Kim SH, Chung JM (1994) Behavioral Signs of Ongoing Pain and Cold Allodynia in a Rat Model of Neuropathic Pain. Pain 59:369–376Google Scholar
  7. 7.
    Dixon WJ (1980) Efficient Analysis of Experimental Observations. Ann Rev Phar Tox 20:441–462Google Scholar
  8. 8.
    Hashizume H, Rutkowski MD, Weinstein JN, DeLeo JA (2000) Central Administration of Methotrexate Reduces Mechanical Allodynia in an Animal Model of Radiculopathy/Sciatica. Pain 87:159–169Google Scholar
  9. 9.
    Kim SH, Chung JM (1992) An Experimental Model for Peripheral Neuropathy Produced by Segmental Spinal Nerve Ligation in the Rat. Pain 50:355–363Google Scholar
  10. 10.
    Leem JW, Willis WD, Chung JM (1993) Cutaneous Sensory Receptors in the Rat Foot. J. Neurophysiol. 69:1684–1699Google Scholar
  11. 11.
    Lindblom U, Merskey H, Mumford JM, Nathan PW, Noordenbos W, Sunderland S (1986) Pain Terms, A Current List with Definitions and Notes on Usage. Pain Supl 3:215–221Google Scholar
  12. 12.
    Ma Q-P, Woolf CJ (1996) Progressive Tactile Hypersensitivity: An Inflammation-Induced Incremental Increase in the Excitability of the Spinal Cord. Pain 67:97–106Google Scholar
  13. 13.
    Park SK, Chung K, Chung JM (2000) Effects of Purinergic and Adrenergic Antagonists in a Rat Model of Painful Peripheral Neuropathy. Pain 87:171–179Google Scholar
  14. 14.
    Tal M, Bennett GJ (1994) Extra-Territorial Pain in Rats with a Peripheral Mononeuropathy: Mechano-Hyperalgesia and Mechano-Allodynia in the Territory of an Uninjured Nerve. Pain 57:375–382Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  • Kyungsoon Chung
    • 1
  1. 1.Department of Anatomy and NeurosciencesUniversity of Texas Medical BranchGalvestonUSA