Allodynia in Fibromyalgia
A lowered pain threshold characterizes the examination findings in fibromyalgia. Allodynia can be caused in animal systems by strategic manipulation of nociceptive neurochemicals. Studies of the nociceptive neurochemicals in FMS spinal fluid have found them to be abnormal in concentration and/or correlated with the symptoms. As a result, FMS can now be identified as chronic, widespread allodynia. These observations change the way FMS is viewed, and identify it as a remarkably interesting human syndrome of chronic central neurochemical pain amplification.