Adjuvant Analgesics in Management of Cancer-Rated Bone Pain
Malignant Bone Pain; boney pain; cancer-related bone pain
Adjuvant analgesics in the management of cancer-related bone pain are supplemental treatments that are added to the primary analgesics, usually NSAIDs and opioids. These additional analgesic interventions include radiation, using either palliative radiotherapy or radiopharmaceuticals, and two classes of medications, bisphosphonates and steroids.
Normal bone undergoes constant remodeling in which resorption or formation of bone occurs. The cells involved in these processes are osteoblasts and osteoclasts, respectively. These cells respond to signals from several types of mediators, including hormones, prostaglandins, and cytokines. Tumor cells invade bone and interrupt the balance between osteoblastic and osteoclastic activity, alter bone integrity and produce pain (Mercadante 1997).
Boney cancers can be exquisitely painful. The severity of pain does not always correlate with...
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