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Study of T Cell Immunosenescence in Various Tissue Compartments

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Handbook of Immunosenescence

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Abstract

Age-associated changes in the human immune response are largely attributed to alterations in T cell function and maintenance; however, most studies of human immunosenescence derive from the sampling of human blood, while the majority of T cells are noncirculating and reside in tissue sites. Discussed in this chapter is how human T cell development, differentiation, and maintenance are highly compartmentalized in distinct tissue sites: T cell development occurs in the thymus, new thymic emigrants populate lymphoid sites where they are initially primed. Activated T cells subsequently leave lymphoid tissue and migrate to mucosal and other peripheral tissues, and specific memory T cell subsets migrate through circulation, lymphoid, and/or peripheral tissues, or take up residence in multiple sites. Throughout life, each type of tissue site exhibits distinct kinetics and qualitative changes with age, with the extent of T cell aging related to the specific anatomic location. These site-specific effects of age on the T cell response have important implications for understanding changes in the immune response to infections and vaccination with age, and how persistent infections can impact T cell homeostasis in tissues with aging.

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Author information

Authors and Affiliations

  1. Columbia Center for Translational Immunology, Columbia University Medical Center, New York, NY, USA

    Michelle Miron, Joseph J. C. Thome, Claire L. Gordon & Donna L. Farber

  2. Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY, USA

    Michelle Miron, Joseph J. C. Thome & Donna L. Farber

  3. Department of Medicine, Columbia University Medical Center, NY, New York, USA

    Claire L. Gordon

  4. Department of Surgery, Columbia University Medical Center, New York, NY, USA

    Donna L. Farber

Authors
  1. Michelle Miron
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  2. Joseph J. C. Thome
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  3. Claire L. Gordon
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  4. Donna L. Farber
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Corresponding author

Correspondence to Donna L. Farber .

Editor information

Editors and Affiliations

  1. Division of Geriatrics Research Center on Aging, University of Sherbrooke Department of Medicine, Sherbrooke, QC, Canada

    Tamas Fulop

  2. Department of Experimental Pathology, University of Bologna, Bologna, Italy

    Claudio Franceschi

  3. Institute for Health and Life Sciences, Tokyo, Japan

    Katsuiku Hirokawa

  4. Center for Medical Research, University of Tübingen, Tübingen, Germany

    Graham Pawelec

Section Editor information

  1. Research Center on Aging, Department of Medicine, Immunology Graduate Programme, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada

    Tamas Fulop

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Miron, M., Thome, J.J., Gordon, C.L., Farber, D.L. (2019). Study of T Cell Immunosenescence in Various Tissue Compartments. In: Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G. (eds) Handbook of Immunosenescence. Springer, Cham. https://doi.org/10.1007/978-3-319-99375-1_79

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