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Using Insects as Models of Immunosenescence

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Handbook of Immunosenescence

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Abstract

Most organisms exhibit physiological decline with advancing age and understanding the causes of this decline is a fundamental goal of aging research. Insect models have been a key model for understanding the general process of aging (Hughes and Reynolds (Annu Rev Entomol 50:421–445, 2005); Lee et al. (Entomol Res 45:1–8, 2015)) although most studies to date have focused on understanding factors regulating life span. However, there is growing awareness that understanding the physiological and genetic basis of age-related decline in traits that influence healthspan (e.g., locomotion, and the immune response to infection) will provide new insight into the process of senescence. This chapter updates my previous review (Leips 2009) on the use of insects as models of immunosenescence. In preparing this update it became clear that while insects have provided insights into the causes of immunosenescence, they have yet to be fully exploited in this area. The hope is that by highlighting particular areas where insects have advanced our knowledge of immunosenescence, it will stimulate greater use of insects to address questions for which they are particularly well-suited.

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Authors and Affiliations

  1. Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, MD, USA

    Jeff Leips

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  1. Jeff Leips
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Correspondence to Jeff Leips .

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Editors and Affiliations

  1. Division of Geriatrics Research Center on Aging, University of Sherbrooke Department of Medicine, Sherbrooke, QC, Canada

    Tamas Fulop

  2. Department of Experimental Pathology, University of Bologna, Bologna, Italy

    Claudio Franceschi

  3. Institute for Health and Life Sciences, Tokyo, Japan

    Katsuiku Hirokawa

  4. Center for Medical Research, University of Tübingen, Tübingen, Germany

    Graham Pawelec

Section Editor information

  1. Research Center on Aging, Department of Medicine, Immunology Graduate Programme, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada

    Tamas Fulop

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Leips, J. (2019). Using Insects as Models of Immunosenescence. In: Fulop, T., Franceschi, C., Hirokawa, K., Pawelec, G. (eds) Handbook of Immunosenescence. Springer, Cham. https://doi.org/10.1007/978-3-319-99375-1_4

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