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Specification of Cerebellar and Precerebellar Neurons

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Handbook of the Cerebellum and Cerebellar Disorders

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Abstract

The cerebellum is thought to participate in the regulation of movement and is comprised of various types of neurons in the cerebellar cortex and nuclei. Each type of neurons has morphologically, immunohistochemically, and electrophysiologically distinct characteristics. In addition, there are two precerebellar afferent systems, the mossy fiber (MF) system and the climbing fiber (CF) system. MF neurons are located in various nuclei throughout the brainstem and send their axons to cerebellar granule cells, whereas CF neurons reside exclusively in the inferior olivary nucleus (ION) and project to Purkinje cells. Recently developed genetic lineage-tracing methods as well as gene-transfer technologies have accelerated the studies on the molecular machinery to specify neuronal subtypes in the cerebellum and the precerebellar systems.

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Authors and Affiliations

  1. Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan

    Mikio Hoshino, Satoshi Miyashita, Yusuke Seto & Mayumi Yamada

  2. Laboratory of Developmental Systems, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan

    Yusuke Seto

  3. Laboratory of Brain Development and Regeneration, Graduate School of Biostudies, Kyoto University, Kyoto, Japan

    Mayumi Yamada

Authors
  1. Mikio Hoshino
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  2. Satoshi Miyashita
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  3. Yusuke Seto
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  4. Mayumi Yamada
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Corresponding author

Correspondence to Mikio Hoshino .

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Editors and Affiliations

  1. Bruxelles, Belgium

    Mario Manto

  2. Scripps Research Institute Dept. Neuropharmacology, La Jolla, CA, USA

    Donna Gruol

  3. Dept. Neurology, Harvard Medical School Massachusetts General Hospital, Boston, MA, USA

    Jeremy Schmahmann

  4. Gunma University Dept. Integrative Physiology, Maebashi, Gunma, Japan

    Noriyuki Koibuchi

  5. Dept Pathology & Immunology & Neuro, Baylor College of Medicine Dept Pathology & Immunology & Neuro, Houston, TX, USA

    Roy Sillitoe

Section Editor information

  1. Department of Pathology and Immunology, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute, Houston, TX, USA

    Roy V. Sillitoe

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Hoshino, M., Miyashita, S., Seto, Y., Yamada, M. (2019). Specification of Cerebellar and Precerebellar Neurons. In: Manto, M., Gruol, D., Schmahmann, J., Koibuchi, N., Sillitoe, R. (eds) Handbook of the Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-97911-3_5-2

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  • DOI: https://doi.org/10.1007/978-3-319-97911-3_5-2

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