Abstract
Many pathological processes can affect the cerebellum, often with overlapping imaging features but, in some cases, with particular radiological findings. The purpose of this chapter is to provide a concise and systematic review of cerebellar pathologies based on their imaging features that can be used for their diagnosis.
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References
Abdelhalim AN, Alberico RA, Barczykowski AL, Duffner PK (2014) Patterns of magnetic resonance imaging abnormalities in symptomatic patients with Krabbe disease correspond to phenotype. Pediatr Neurol 50(2):127–134. https://doi.org/10.1016/j.pediatrneurol.2013.10.001
Ariyani W, Khairinisa MA, Perrotta G, Manto M, Koibuchi N (2017) The effects of gadolinium-based contrast agents on the cerebellum: from basic research to neurological practice and from pregnancy to adulthood. Cerebellum. https://doi.org/10.1007/s12311-017-0903-4
Bosemani T, Poretti A (2016) Cerebellar disruptions and neurodevelopmental disabilities. Semin Fetal Neonatal Med 21(5):339–348. https://doi.org/10.1016/j.siny.2016.04.014
Bricout M, Grevent D, Lebre AS, Rio M, Desguerre I, De Lonlay P, Valayannopoulos V, Brunelle F, Rotig A, Munnich A, Boddaert N (2014) Brain imaging in mitochondrial respiratory chain deficiency: combination of brain MRI features as a useful tool for genotype/phenotype correlations. J Med Genet 51(7):429–435. https://doi.org/10.1136/jmedgenet-2013-102256
Brooks DJ, Seppi K, Neuroimaging Working Group on MSA (2009) Proposed neuroimaging criteria for the diagnosis of multiple system atrophy. Mov Disord 24(7):949–964. https://doi.org/10.1002/mds.22413
Chatterjee D, Radotra BD, Vasishta RK, Sharma K (2015) Vascular complications of tuberculous meningitis: an autopsy study. Neurol India 63(6):926–932
Cohen OS, Hoffmann C, Lee H, Chapman J, Fulbright RK, Prohovnik I (2009) MRI detection of the cerebellar syndrome in Creutzfeldt-Jakob disease. Cerebellum 8(3):373–381. https://doi.org/10.1007/s12311-009-0106-8
Daghistani R, Rutka J, Widjaja E (2015) MRI characteristics of cerebellar tubers and their longitudinal changes in children with tuberous sclerosis complex. Childs Nerv Syst 31(1):109–113. https://doi.org/10.1007/s00381-014-2542-0
Datar S, Rabinstein AA (2014) Cerebellar hemorrhage. Neurol Clin 32(4):993–1007. https://doi.org/10.1016/j.ncl.2014.07.006
De Cocker LJ, van Veluw SJ, Fowkes M, Luijten PR, Mali WP, Hendrikse J (2013) Very small cerebellar infarcts: integration of recent insights into a functional topographic classification. Cerebrovasc Dis 36(2):81–87. https://doi.org/10.1159/000353668
De Cocker LJ, Lovblad KO, Hendrikse J (2017) MRI of cerebellar infarction. Eur Neurol 77(3–4):137–146. https://doi.org/10.1159/000455229
de Souza A, Narvencar KP, Sindhoora KV (2013) The neurological effects of methyl bromide intoxication. J Neurol Sci 335(1–2):36–41. https://doi.org/10.1016/j.jns.2013.09.022
Deistung A, Stefanescu MR, Ernst TM, Schlamann M, Ladd ME, Reichenbach JR, Timmann D (2016) Structural and functional magnetic resonance imaging of the cerebellum: considerations for assessing cerebellar ataxias. Cerebellum 15(1):21–25. https://doi.org/10.1007/s12311-015-0738-9
Eichler F, Grodd W, Grant E, Sessa M, Biffi A, Bley A, Kohlschuetter A, Loes DJ, Kraegeloh-Mann I (2009) Metachromatic leukodystrophy: a scoring system for brain MR imaging observations. AJNR Am J Neuroradiol 30(10):1893–1897. https://doi.org/10.3174/ajnr.A1739
Fitzgerald RT, Samant RS, Kumar M, Van Hemert R, Angtuaco EJ (2015) Features of infratentorial-predominant posterior reversible encephalopathy syndrome. Acta Neurol Belg 115(4):629–634. https://doi.org/10.1007/s13760-015-0431-2
Gao L, Han F, Jin Y, Xiong J, Lv Y, Yao Z, Zhang J (2017) Imaging features of rosette-forming glioneuronal tumours. Clin Radiol. https://doi.org/10.1016/j.crad.2017.10.011
Gardeur D, Buge A, Rancurel G, Dechy H, Metzger J (1978) Bismuth encephalopathy and cerebral computed tomography. J Comput Assist Tomogr 2(4):436–438
Gonzalez-Suarez I, Aguilar-Amat MJ, Trigueros M, Borobia AM, Cruz A, Arpa J (2014) Leukoencephalopathy due to oral methotrexate. Cerebellum 13(1):178–183. https://doi.org/10.1007/s12311-013-0528-1
Griffiths PD, Blaser S, Mukonoweshuro W, Armstrong D, Milo-Mason G, Cheung S (1999) Neurofibromatosis bright objects in children with neurofibromatosis type 1: a proliferative potential? Pediatrics 104(4):e49
Hortobagyi T, Wise S, Hunt N, Cary N, Djurovic V, Fegan-Earl A, Shorrock K, Rouse D, Al-Sarraj S (2007) Traumatic axonal damage in the brain can be detected using beta-APP immunohistochemistry within 35 min after head injury to human adults. Neuropathol Appl Neurobiol 33(2):226–237. https://doi.org/10.1111/j.1365-2990.2006.00794.x
Huang BY, Castillo M (2008) Hypoxic-ischemic brain injury: imaging findings from birth to adulthood. Radiographics 28(2):417–439.; quiz 617. https://doi.org/10.1148/rg.282075066
Iwasaki Y (2017) Creutzfeldt-Jakob disease. Neuropathology 37(2):174–188. https://doi.org/10.1111/neup.12355
Jacquemont S, Hagerman RJ, Leehey M, Grigsby J, Zhang L, Brunberg JA, Greco C, Des Portes V, Jardini T, Levine R, Berry-Kravis E, Brown WT, Schaeffer S, Kissel J, Tassone F, Hagerman PJ (2003) Fragile X premutation tremor/ataxia syndrome: molecular, clinical, and neuroimaging correlates. Am J Hum Genet 72(4):869–878. https://doi.org/10.1086/374321
Kim JE, Kim SM, Ahn SW, Lim BC, Chae JH, Hong YH, Park KS, Sung JJ, Lee KW (2011) Brain abnormalities in neuromyelitis optica. J Neurol Sci 302(1–2):43–48. https://doi.org/10.1016/j.jns.2010.12.001
Klein JL, Lemmon ME, Northington FJ, Boltshauser E, Huisman TA, Poretti A (2016) Clinical and neuroimaging features as diagnostic guides in neonatal neurology diseases with cerebellar involvement. Cerebellum Ataxias 3:1. https://doi.org/10.1186/s40673-016-0039-1
Korogi Y, Takahashi M, Okajima T, Eto K (1998) MR findings of Minamata disease – organic mercury poisoning. J Magn Reson Imaging 8(2):308–316
Kriegstein AR, Shungu DC, Millar WS, Armitage BA, Brust JC, Chillrud S, Goldman J, Lynch T (1999) Leukoencephalopathy and raised brain lactate from heroin vapor inhalation (“chasing the dragon”). Neurology 53(8):1765–1773
Lang EW, Ren Ya Z, Preul C, Hugo HH, Hempelmann RG, Buhl R, Barth H, Klinge H, Mehdorn HM (2001) Stroke pattern interpretation: the variability of hypertensive versus amyloid angiopathy hemorrhage. Cerebrovasc Dis 12(2):121–130. https://doi.org/10.1159/000047691
Li D, Lian L, Zhu S (2015) Isolated cerebellar involvement in posterior reversible encephalopathy syndrome. J Neurol Sci 357(1–2):101–105. https://doi.org/10.1016/j.jns.2015.07.004
Mahadevan A, Ramalingaiah AH, Parthasarathy S, Nath A, Ranga U, Krishna SS (2013) Neuropathological correlate of the “concentric target sign” in MRI of HIV-associated cerebral toxoplasmosis. J Magn Reson Imaging 38(2):488–495. https://doi.org/10.1002/jmri.24036
Martin MH, Bouchard JP, Sylvain M, St-Onge O, Truchon S (2007) Autosomal recessive spastic ataxia of Charlevoix-Saguenay: a report of MR imaging in 5 patients. AJNR Am J Neuroradiol 28(8):1606–1608. https://doi.org/10.3174/ajnr.A0603
Nie S, Chen G, Cao X, Zhang Y (2014) Cerebrotendinous xanthomatosis: a comprehensive review of pathogenesis, clinical manifestations, diagnosis, and management. Orphanet J Rare Dis 9:179. https://doi.org/10.1186/s13023-014-0179-4
Parrish JB, Weinstock-Guttman B, Yeh EA (2010) Cerebellar mutism in pediatric acute disseminated encephalomyelitis. Pediatr Neurol 42(4):259–266. https://doi.org/10.1016/j.pediatrneurol.2009.11.003
Pfiffner TJ, Jani R, Mechtler L (2014) Neuro-oncological disorders of the cerebellum. Neurol Clin 32(4):913–941. https://doi.org/10.1016/j.ncl.2014.07.011
Poretti A, Boltshauser E, Doherty D (2014) Cerebellar hypoplasia: differential diagnosis and diagnostic approach. Am J Med Genet C: Semin Med Genet 166C(2):211–226. https://doi.org/10.1002/ajmg.c.31398
Poretti A, Boltshauser E, Huisman TA (2016a) Cerebellar and brainstem malformations. Neuroimaging Clin N Am 26(3):341–357. https://doi.org/10.1016/j.nic.2016.03.005
Poretti A, Boltshauser E, Huisman TA (2016b) Pre- and postnatal neuroimaging of congenital cerebellar abnormalities. Cerebellum 15(1):5–9. https://doi.org/10.1007/s12311-015-0699-z
Pruitt AA (2014) Infections of the cerebellum. Neurol Clin 32(4):1117–1131. https://doi.org/10.1016/j.ncl.2014.07.009
Shimazaki H, Takiyama Y, Honda J, Sakoe K, Namekawa M, Tsugawa J, Tsuboi Y, Suzuki C, Baba M, Nakano I (2013) Middle cerebellar peduncles and pontine T2 hypointensities in ARSACS. J Neuroimaging 23(1):82–85. https://doi.org/10.1111/j.1552-6569.2011.00647.x
Smith RW, Ellison DW, Jenkins EA, Gallagher PJ, Cawley MI (1994) Cerebellum and brainstem vasculopathy in systemic lupus erythematosus: two clinico-pathological cases. Ann Rheum Dis 53(5):327–330
Srivastava S, Naidu S (1993) Alexander disease. In: Adam MP, Ardinger HH, Pagon RA et al. (eds) GeneReviews((R)). Seattle, University of Washington
Stezin A, Lenka A, Jhunjhunwala K, Saini J, Pal PK (2017) Advanced structural neuroimaging in progressive supranuclear palsy: where do we stand? Parkinsonism Relat Disord 36:19–32. https://doi.org/10.1016/j.parkreldis.2016.12.023
Takeuchi S, Takasato Y, Masaoka H, Hayakawa T (2011) Traumatic intra-cerebellar haematoma: study of 17 cases. Br J Neurosurg 25(1):62–67. https://doi.org/10.3109/02688697.2010.500410
Tobin WO, Guo Y, Krecke KN, Parisi JE, Lucchinetti CF, Pittock SJ, Mandrekar J, Dubey D, Debruyne J, Keegan BM (2017) Diagnostic criteria for chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS). Brain 140(9):2415–2425. https://doi.org/10.1093/brain/awx200
Toelle SP, Poretti A, Weber P, Seute T, Bromberg JE, Scheer I, Boltshauser E (2015) Cerebellar hypoplasia and dysmorphia in neurofibromatosis type 1. Cerebellum 14(6):642–649. https://doi.org/10.1007/s12311-015-0658-8
Wilkins A (2017) Cerebellar dysfunction in multiple sclerosis. Front Neurol 8:312. https://doi.org/10.3389/fneur.2017.00312
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Rapalino, O. (2021). Radiographic Features of Cerebellar Disease: Imaging Approach to Differential Diagnosis. In: Manto, M., Gruol, D., Schmahmann, J., Koibuchi, N., Sillitoe, R. (eds) Handbook of the Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-97911-3_27-2
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