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Development of Glutamatergic and GABAergic Synapses

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Book cover Handbook of the Cerebellum and Cerebellar Disorders

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Abstract

More than a century ago, Santiago Ramón y Cajal based on the cerebellum his initial description of neurons labeled with the silver impregnation method, obtaining evidence in favor of the neuron doctrine. It is perhaps less known that Ramón y Cajal also made an accurate description of cerebellar development, laying the foundation for successive studies of cell migration, neuronal differentiation, and synaptogenesis. Building on this work, subsequent analyses of cerebellar development have greatly increased the understanding of cellular and molecular events that regulate the assembly of synaptic circuits in the central nervous system. What makes the cerebellum a particularly useful model system is its delayed course of development, largely extending into postnatal life. This chapter describes the current state of knowledge relating to cerebellar synapse development, highlighting recent studies on the molecular and activity-dependent mechanisms that control the spatial specificity of synaptogenesis.

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Authors and Affiliations

  1. Department of Neuroscience “Rita Levi Montalcini”, National Institute of Neuroscience-Italy, Turin, Italy

    Marco Sassoè-Pognetto

  2. Chica und Heinz Schaller-Stiftung Research Group, German Cancer Research Center (DKFZ), Heidelberg, Germany

    Annarita Patrizi

Authors
  1. Marco Sassoè-Pognetto
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  2. Annarita Patrizi
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Corresponding author

Correspondence to Marco Sassoè-Pognetto .

Editor information

Editors and Affiliations

  1. Bruxelles, Belgium

    Mario Manto

  2. Scripps Research Institute Dept. Neuropharmacology, La Jolla, CA, USA

    Donna Gruol

  3. Dept. Neurology, Harvard Medical School Massachusetts General Hospital, Boston, MA, USA

    Jeremy Schmahmann

  4. Gunma University Dept. Integrative Physiology, Maebashi, Gunma, Japan

    Noriyuki Koibuchi

  5. Dept Pathology & Immunology & Neuro, Baylor College of Medicine Dept Pathology & Immunology & Neuro, Houston, TX, USA

    Roy Sillitoe

Section Editor information

  1. Department of Pathology and Immunology, Baylor College of Medicine, Jan and Dan Duncan Neurological Research Institute, Houston, TX, USA

    Roy V. Sillitoe

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Sassoè-Pognetto, M., Patrizi, A. (2019). Development of Glutamatergic and GABAergic Synapses. In: Manto, M., Gruol, D., Schmahmann, J., Koibuchi, N., Sillitoe, R. (eds) Handbook of the Cerebellum and Cerebellar Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-97911-3_12-2

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  • DOI: https://doi.org/10.1007/978-3-319-97911-3_12-2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-97911-3

  • Online ISBN: 978-3-319-97911-3

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