Definitions
- Child:
-
A human from birth through his or her eighteenth year of life. Further subcategories include neonate, less than 1 month; infant, 1 month to 12 months; toddler, 1 year to 3 years; child, 4 years to 10 years; and adolescent, 11 years to 18 years.
- Pharmacodynamics (toxicodynamics):
-
The study of the relationship between chemical amount or concentration and response.
- Pharmacogenomics (toxicogenomics):
-
The study of how variant forms of human genes contribute to interindividual variability in chemical response.
- Pharmacokinetics (toxicokinetics):
-
The study of the movement of a chemical throughout the body and the concentrations (or amounts) which reach a given body space and/or tissue and its residence time. It includes characteristics which provide the dose-concentration-effect relationship: absorption, distribution, metabolism, and excretion.
Introduction
The World Health Organization’s (WHO) 5-year strategic plan is a broad initiative to address the many challenges facing...
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References
Arnold SF, Price PS, the LifeLine Group (2007) Toxicol Appl Pharmacol 223:121–124
Becker K, Seiwert M, Casteleyn L, Joas R, Joas A et al (2014) A systemic approach for designing a HBM Pilot Study for Europe. Int J Hyg Environ Health 217:312–322
Bell SM, Phillips J, Sedykh A et al (2017) An integrated chemical environment to support 21st-century toxicology. Environ Health Perspect 125:054501
Billionnet C, Sherrill D, Annesi-Maesano I (2012) Estimating the health effects of exposure to multi-pollutant mixture. Ann Epidemiol 22:126–141
Birnbaum L (2016) Informing 21st-century risk assessments with 21st-century science. In: Environmental health perspectives, vol 124, pp A60–A63
Centers for Disease Control and Prevention (2019) National Health and Nutrition Examination Survey. https://www.cdc.gov/nchs/nhanes/index.htm. Accessed 21 Jan 2019
Cherkosov A, Muratov EN, Fourches D, Varnek A, Baskin II et al (2014) QSAR modelling: where have you been? Where are you going to? J Med Chem 57:4977–5010
Cho HJ, Kim JE, Kim DD, Yoon IS (2014) In vitro-in vivo extrapolation (IVIVE) for predicting human intestinal absorption and first pass metabolism. Drug Dev Ind Pharm 14:989–998
De B, Bhandarai K, Mukherjee R et al (2017) PBPK modelling- a predictive, eco-friendly, biw-waiver tool for drug research. Curr Drug Discov Technol 14:142–155
El-Masri H, Kleinstreuer N, Hines RN et al (2016) Integration of life-stage physiologicaly based pharmacokinetic models with adverse outcome pathways and environmental exposure models to screen for environmental hazards. Toxicol Sci 152:230–243
Fabrega F, Kumar V, Schuhmacher M, Domingo JL, Nadal M (2014) PBPK modelling for PFOS and PFOA: validation with human experimental data. Toxicol Lett 230:244–251
Feghali M, Venkataramanan V, Caritis S (2015) Pharmacokinetics of drugs in pregnancy. Semin Perinatol 39:512–519
Filer DL, Kothiya P, Setzer RW et al (2017) tcpl: the ToxCast pipeline for high-throughput screening data. Bioinformatics 33:618–620
Groothuis FA, Heringa MB, Nicol B, Hermens JL, Blaauboer BJ, Kramer KI (2015) Dose metric considerations in in vitro assays to improve quantitative in vitro-in vivo extrapolations. Toxicology 332:30–40
Hartmanshenn C, Scherholz M, Androulakis IP (2016) Physiologically-based pharmacokinetic models: approaches for enabling personalized medicine. J Pharmacokinet Pharmacodyn 43:481–504
Hubal EAC, de Wet T, Toit LD et al (2014) Identifying important life stages for monitoring and assessing risks from exposures to environmental contaminants: results of a World Health Organization review. Regul Toxicol Pharmacol 69:113–124
Jogiraju VK, Avvari S, Gollen R, Taft DR (2017) Application of physiologically based pharmacokinetic modelling to predict drug disposition in pregnant populations. Biopharm Drug Dispos 38:426–438
Jones HM, Chen Y, Gibson C et al (2015) Physiologically based pharmacokinetic modelling in drug discovery and development: a pharmaceutical industry perspective. Clin Pharmacol Ther 97:247–262
Judson RS, Martin MT, Egeghy P et al (2012) Aggregating data for computational toxicology applications: the U.S., Environmental Protection Agency Aggregated Computational Toxicology Resource (ACToR) system. Int J Mol Sci 13:1805–1831
Judson R, Houck K, Martin M et al (2014) In vitro and modelling approaches to risk assessment from the U.S. Environmental Protection Agency ToxCast Programme. Basic Clin Pharmacol Toxicol 115:69–76
Kavlock R, Dix D (2010) Computational toxicology as implemented by the US EPA: providing high throughput decision support tools for screening and assessing chemical exposure, hazard and risk. J Toxicol Environ Health 13:197–121
Kearns GL, Abdel-Rahman SM, Alander SW, Blowey DL, Leeder JS, Kauffman RE (2003) Developmental pharmacology – drug disposition, action, and therapy in infants and children. N Engl J Med 349:1157–1167
Lou I, Wambaugh JF, Lau C, Hanson RG, Lindstrom AB, Strynar MJ, Zehr RD, Setzer RW, Barton HA (2009) Modeling single and repeated dose pharmacokinetics of PFOA in mice. Toxicol Sci 107:331–341
Louis GB, Damstra T, Diaz-Berriga SLP et al (2006) Principles for evaulating health risks in children associated with exposures to chemicals. Environmental health criteria. https://www.who.int/ipcs/publications/ehc/ehc237.pdf?ua=1. Accessed 13 May 2019
Mangoni AA, Jackson SHD (2003) Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications. Br J Clin Pharmacol 57:6–14
Marsousi N, Desmeules JA, Rudaz S, Daali Y (2017) Usefulness of PBPK modelling in incorporation of clinical conditions in personalized medicine. J Pharm Sci 106:2380–2391
Meek ME, Boobis AR, Crofton KM, Heinemeyer G, Van Raaij M, Vickers C (2011) Risk assessment of combined exposure to multiple chemicals: a WHO/IPCS framework. Regul Toxicol Pharmacol 60:S1–S14
Metcalf SW, Orloff KG (2004) Biomarkers of exposure in community settings. J Toxicol Environ Health 67:715–726
NLM. National Library of Medicine. National Institute of Health. Toxicology Data Network https://toxnet.nlm.nih.gov/. Accessed 25 Jan 2019
NRC. National Research Council (2007) Toxicity testing in the 21st century: A vision and a strategy. Washington, DC: National Research Council of the National Academies. http://bit.ly/2Bp48Aq. Accessed 21 Jan 2019
NTP. National Toxicology Program. National Institute of Environmental Health Sciences (2019a) Chemical Effects in Biological Systems. https://manticore.niehs.nih.gov/cebssearch/. Accessed 25 Jan 2019
NTP. National Toxicology Program. National Institute of Environmental Health Sciences (2019b) Integrated Chemical Environment. https://ice.ntp.niehs.nih.gov/. Accessed 25 Jan 2019
Olsen GW, Burris JM, Ehresman DJ, Froehlich JW, Seacat AM, Butenhoff JL, Zobel LR (2007) Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers. Environ Health Perspect 115:1298–1305
Paini A, Leonard JA, Joossens E et al (2019) Next generation physiologically based kinetic (NG-PBK) models in support of regulatory decision making. Comput Texicol 9:61–72
Pariente G, Leibson T, Carls A et al (2016) Pregnancy-associated changes in pharmacokinetics: a systematic review. PLoS Med 13:e1002160
Pruss-Ustin A, Vickers C, Haefliger P, Bertollini R (2011) Knowns and unknowns on burden of disease due to chemicals: a systemic review. Environ Health 10:9
Sager JE, Yu J, Ragueneau-Majlessi I, Isoherranen N (2015) Physiologically based pharmacokinetic (PBPK) modelling and simulation approaches: a systematic review of published models, applications and model verification. Drug Metab Dispos 43:1823–1837
Sipes NS, Wambaugh JF, Pearce R et al (2017) An intuitive approach for predicting potential human health risk with the Tox21 10k library. Environ Sci Technol 51:10786–10796
Stafoggia M, Breitner S, Hampel R, Basagana X (2017) Statistical approaches to address multi-pollutant mixtures and multiple exposures: the state of the science. Curr Environ Health Rep 4:481–490
Teorell T (1937) Kinetics of distribution of substances administered to the body. I. The extravascular modes of administration. Arch Int Pharmacodyn Ther 57:205–225
Thomas RS, Paules RS, Simeonov A, Fitzpatrick SC, Crofton KM et al (2018) The US Federal Tox21 Program: a strategic and operational plan for continued leadership. ALTEX 35:163–168
USEPA (U.S. Environmental Protection Agency) (2019) Integrated Risk Information System. https://www.epa.gov/iris. Accessed 22 Jan 2019
USFDA (U.S. Food and Drug Administration) Best Pharmaceuticals for Children Act. https://www.fda.gov/ScienceResearch/SpecialTopics/PediatricTherapeuticsResearch/ucm509707.htm. Accessed 27 Jan 2019
WHO (2016) World Health Organization. International Programme on Chemical Safety. The public health impact of chemicals: Knowns and unknowns. http://apps.who.int/iris/bitstream/handle/10665/206553/WHO_FWC_PHE_EPE_16.01_eng.pdf?sequence=1
WHO (2019a) World Health Organization. 13th General Programme of Work (GPW13): WHO impact framework white paper. 29 October 2018 https://www.who.int/about/what-we-do/gpw-thirteen-consultation/en/
WHO (2019b) World Health Organization. Listing of IPCS publications and projects on risk assessment methodology. https://www.who.int/ipcs/publications/ehc/methodology_alphabetical/en/
Williams AJ, Grulke CM, Edwards J et al (2017) The CompTox Chemistry Dashboard: a community data resource for environmental chemistry. Journal of Cheminformatics 9:61
Worley RR, Fisher J (2015) Application of physiologically-based pharmacokinetic modelling to explore the role of kidney transporters in renal reabsorption of perfluorooctanic acid in the rat. Toxicol Appl Pharmacol 289:428–441
Worley RR, Yang X, Fisher J (2017) Physiologically based pharmacokinetic modelling of human exposure to perfluorooctanioic acid suggests historical non drinking-water exposures are important for predicting current serum concentrations. Toxicol Appl Pharmacol 330:9–21
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Lowry, J.A. (2020). Assessment of Exposures in Vulnerable Populations: Exposure and Response Modelling for Environmental Contaminants Through a Lifetime. In: Leal Filho, W., Wall, T., Azul, A.M., Brandli, L., Özuyar, P.G. (eds) Good Health and Well-Being. Encyclopedia of the UN Sustainable Development Goals. Springer, Cham. https://doi.org/10.1007/978-3-319-95681-7_73
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