Synonyms
Inflammatory pseudotumor of the spleen
Definition
In 2004, Martel et al. reported 25 cases of a unique distinctive lesion of the spleen, constituted by multiple nodules realizing a single mass in the center of the organ. These well-circumscribed lesions show a peculiar vascular pattern, with a distinctive immunophenotype profile and a benign evolution. They propose the term sclerosing angiomatoid nodular transformation (SANT) of the spleen red pulp. A few years later, we published another series of 16 cases of patients (Diebold et al. 2008), presenting the same lesions in the spleen, which have been often diagnosed before as inflammatory pseudotumor (IPT).
It can be postulated (Martel et al. 2004) that this peculiar transformation of the red pulp of the spleen may represent an exaggerated response of stromal proliferation to a disruption of the small vascular outflow tracts leading to hyperplasia of the proximal vascular bed, with nodular changes and fibrosis.
The lesions of...
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References and Further Reading
Bagul KA, Sen A. (2015). Sclerosing angiomatoid nodular transformation of spleen masquerading as a splenic abscess. Indian J Pathol Microbiol, 58(3), 359–61.
Cao, J. Y., Zhang, H., & Wang, W. P. (2010). Ultrasonography of sclerosing angiomatoid nodular transformation in the spleen. World Journal of Gastroenterology, 16(29), 3727–3730.
Chang, K. C., Lee, J.-C., Wang, Y.-C., et al. (2016). Polyclonality in Sclerosing Angiomatoid nodular transformation of the spleen. The American Journal of Surgical Pathology, 40, 1343–1351.
Chapel, F., Baume, B., & Bereder, J. M. (1999). Unusual vascular changes in the red pulp of the spleen accompanying breast carcinoma metastasis. Pathology, Research and Practice, 195, 53–56. With critical commentary from: Diebold J, same journal p.58.
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Diebold, J., Audouin, J., Le Tourneau, A., Molina, T.J. (2020). Sclerosing Angiomatoid Nodular Transformation (SANT) of the Splenic Red Pulp. In: Molina, T.J. (eds) Hematopathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-95309-0_5014
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DOI: https://doi.org/10.1007/978-3-319-95309-0_5014
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