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Burkitt Lymphoma

  • Reference work entry
  • First Online:
Hematopathology

Part of the book series: Encyclopedia of Pathology ((EP))

  • 1170 Accesses

Synonyms

African lymphoma; Small noncleaved cell lymphoma

Definition

Burkitt lymphoma (BL) is defined in the last 2017 World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissues as a mature highly aggressive B-cell neoplasm, often presenting at extranodal sites or as an acute leukemia, composed of monomorphic, medium-sized B-cells with basophilic cytoplasm and a high mitotic rate. Translocation involving MYC is the most frequent genetic feature. Epstein–Barr virus (EBV) is found in a variable proportion of cases. BL has often been referred to as The Rosetta Stone of Cancer because it was the first human cancer for which a viral association has been shown and a chromosomal translocation resulting in the activation of an oncogene was identified, and the first tumor to be successfully treated with chemotherapy alone.

The first description of BL was probably that of Albert Cook: one of Cook’s patients in Mulago Hospital (Uganda) was a child with a large...

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References and Further Reading

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Authors and Affiliations

  1. Section of Pathology, Department of Medical Biotechnology, University of Siena, Siena, Italy

    Maria Raffaella Ambrosio, Bruno Jim Rocca & Lorenzo Leoncini

Authors
  1. Maria Raffaella Ambrosio
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  2. Bruno Jim Rocca
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  3. Lorenzo Leoncini
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Corresponding author

Correspondence to Lorenzo Leoncini .

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Editors and Affiliations

  1. Department of Pathology, Paris Descartes University, University of Paris, Necker-Enfants Malades Hospital, AP-HP, Paris, France

    Thierry J. Molina

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Ambrosio, M.R., Rocca, B.J., Leoncini, L. (2020). Burkitt Lymphoma. In: Molina, T.J. (eds) Hematopathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-95309-0_3837

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  • DOI: https://doi.org/10.1007/978-3-319-95309-0_3837

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-95308-3

  • Online ISBN: 978-3-319-95309-0

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