Synonyms
B-cell chronic lymphocytic leukemia/prolymphocytic leukemia (REAL); Chronic lymphocytic leukemia of B-cell type (Kiel); CLL (French-American-British group); CLL/SLL, Malignant lymphoma, diffuse, well-differentiated lymphocytic (Rappaport); Small lymphocytic (consistent with CLL) (Working Formulation); Small lymphocytic B, chronic lymphocytic leukemia (Lukes-Collins)
Definition
Chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL) is a neoplasm of clonal, mature small B-lymphocytes with a frequent leukemic presentation. When lymph nodes are involved in the absence of leukemic disease, the designation of small lymphocytic lymphoma (SLL) is used. In the absence of extramedullary tissue involvement, there must be ≥5.0 × 109/L abnormal B cells in the peripheral blood to establish a diagnosis of chronic lymphocytic leukemia (CLL). The International Workshop on Chronic Lymphocytic Leukemia (IWCLL) allows an exception in that a diagnosis of CLL can be made in the setting...
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References and Further Reading
Chiorazzi, N., Kanti, R. R., & Ferrarini, M. (2005). Chronic lymphocytic leukemkia. The New England Journal of Medicine, 352, 804–815.
Dohner, H., Stilgenbauer, S., Benner A., et al. (2000). Genomic aberrations and survival in chronic lymphocytic leukemia. NEJM, 343(6), 1910–1916.
Hallek, M., Cheson, B. D., Catovsky, D., et al. (2008). Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute - Working Group 1996 guidelines. Blood, 111, 5446–5456.
Matutes, E., Owusu-Ankomah, K., Morilla R., et al. (1994). The immunological profile of B-cell disorders and proposal of a scoring system for the diagnosis of CLL. Leukemia, 8(10), 1640–1645.
Puente, X. S., Pinyol, M., Quesada, V., et al. (2011). Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukemia. Nature, 475, 101–105.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2020 Springer Nature Switzerland AG
About this entry
Cite this entry
Ondrejka, S.L., Hsi, E.D. (2020). B-Cell Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma. In: Molina, T.J. (eds) Hematopathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-95309-0_1899
Download citation
DOI: https://doi.org/10.1007/978-3-319-95309-0_1899
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-95308-3
Online ISBN: 978-3-319-95309-0
eBook Packages: MedicineReference Module Medicine