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Hematopathology pp 1–6Cite as

Acute Leukemia, Ambiguous Lineage

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Part of the book series: Encyclopedia of Pathology ((EP))

Synonyms

Bilineage acute leukemia; Biphenotypic acute leukemia; Mixed-lineage leukemia

Definition

According to the World Health Organization 2008 classification of tumors of hematopoietic and lymphatic tissues, the category “acute leukemia of ambiguous lineage” includes mixed phenotype acute leukemia (MPAL), acute undifferentiated leukemia (AUL), and a provisional entity of natural killer (NK) cell lymphoblastic leukemia/lymphoma (Borowitz et al. 2008) (Table 1).

Acute Leukemia, Ambiguous Lineage, Table 1 WHO 2008 classification of acute leukemias of ambiguous origin and expression of lineage assignment markers for mixed phenotype acute leukemia (MPAL) (Borowitz et al. 2008)
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References and Further Reading

  • Al-Seraihy, A. S., Owaidah, T. M., Ayas, M., El-Solh, H., Al-Mahr, M., Al-Ahmari, A., et al. (2009). Clinical characteristics and outcome of children with biphenotypic acute leukemia. Haematologica, 94, 1682–1690.

    Article  PubMed  PubMed Central  Google Scholar 

  • Borowitz, M., Bene, M. C., Harris, N. C., Porwit, A., & Matutes, E. (2008). Acute leukemia of ambiguous origin. In S. Swerdlow, E. Campo, N. Harris, E. Jaffe, H. Stein, S. A. Pileri, J. Thiele, & J. Vardiman (Eds.), World health organization classification of tumours. Pathology and genetics of tumours of haematopoietic and lymphoid tissues (pp. 150–155). Lyon: IARC Press.

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  • Manola, K. N. (2013). Cytogenetic abnormalities in acute leukaemia of ambiguous lineage: An overview. British Journal of Haematology, 163, 24–39.

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  • Matutes, E., Pickl, W. F., Van’t Veer, M., Morilla, R., Swansbury, J., Strobl, H., et al. (2011). Mixed-phenotype acute leukemia: Clinical and laboratory features and outcome in 100 patients defined according to the WHO 2008 classification. Blood, 117, 3163–3171.

    Article  CAS  PubMed  Google Scholar 

  • Weinberg, O. K., & Arber, D. A. (2010). Mixed-phenotype acute leukemia: Historical overview and a new definition. Leukemia, 24, 1844–1851.

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Laboratory Medicine and Pathobiology, University Health Network, Toronto General Hospital, Toronto, ON, Canada

    Anna Porwit

Authors
  1. Anna Porwit
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Corresponding author

Correspondence to Anna Porwit .

Editor information

Editors and Affiliations

  1. Department of Pathology, Paris Descartes University, University of Paris, Necker-Enfants Malades Hospital, AP-HP, Paris, France

    Thierry J. Molina

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Porwit, A. (2020). Acute Leukemia, Ambiguous Lineage. In: Molina, T.J. (eds) Hematopathology. Encyclopedia of Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-95309-0_1893

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  • DOI: https://doi.org/10.1007/978-3-319-95309-0_1893

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-95308-3

  • Online ISBN: 978-3-319-95309-0

  • eBook Packages: MedicineReference Module Medicine

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