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Cardiovascular and Central Nervous System Toxicity by Anticancer Drugs in Breast Cancer Patients

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Brain and Heart Dynamics

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Abstract

Breast cancer is one of the most malignant diseases, associated with high rate mortality. In this chapter a particular attention is paid on cardiovascular and central nervous system toxicity induced by chemotherapeutic agents used for both primary and metastatic treatment of this life-threatening pathology. With respect to traditional drugs, including anthracyclines, taxanes, fluoropyrimidines, and endocrine therapy, the more recent targeted therapies, such as human epidermal growth factor receptor 2 (HER2) and vascular endothelial growth factor (VEGF), aimed to ameliorate anticancer activity and to reduce toxic effects by affecting more specific molecular sites. However, despite the improvement in breast cancer treatment, these novel drugs were also found to be associated, even if at a lesser extent, with important side effects, such as cardiotoxicity, with consequent heart failure. For this reason, the cardiovascular and neuropsychiatric safety profiles of all anticancer drugs and protocols remain important items to be carefully evaluated in breast cancer patients.

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  1. Dipartimento di Ricerca Traslazionale e delle Nuove Tecnologie in Medicina e Chirurgia, and Museo di Anatomia Umana “Filippo Civinini”, Università di Pisa, Pisa, Italy

    Gianfranco Natale

  2. Dipartimento di Medicina Clinica e Sperimentale, Università di Pisa, Pisa, Italy

    Guido Bocci

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  1. Gianfranco Natale
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  1. Dept of Drug Sciences, Pharmacology Sect, University of Pavia, Dept of Drug Sciences, Pharmacology Sect, Pavia, Pavia, Italy

    Stefano Govoni

  2. Dept of Brain and Behavioural Sciences, University of Pavia Dept of Brain and Behavioural Sciences, Pavia, Pavia, Italy

    Pierluigi Politi

  3. Department of Molecular Medicine, University of Pavia, Department of Molecular Medicine, Pavia, Pavia, Italy

    Emilio Vanoli

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  1. Department of Neurosciences, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy

    Raffaele Coppini

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Natale, G., Bocci, G. (2020). Cardiovascular and Central Nervous System Toxicity by Anticancer Drugs in Breast Cancer Patients. In: Govoni, S., Politi, P., Vanoli, E. (eds) Brain and Heart Dynamics. Springer, Cham. https://doi.org/10.1007/978-3-319-90305-7_50-1

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