Abstract
In this chapter, we provide a general overview of secondary metabolites, especially easily volatilized molecules, namely, VOCs, isolated and identified from endophytic fungal communities of different medicinal plants. A fungal endophyte spends the whole or part of its life cycle colonizing inter- and/or intracellularly inside the healthy tissues of the host plants, causing no apparent symptoms of disease. Endophytic fungi produce a wide array of secondary metabolites and volatile organic compounds with important biological functions, displaying a broad range of useful antibiotic and pharmaceutical activities as well as immunomodulatory and toxic activities. Some of their biological activities are still unknown to mankind. These microbial metabolites have drawn enormous attention as potential agents of medicinal properties. Fungi are well known for emitting a complex mixture of volatile organic compounds (VOCs). Fungal VOCs commonly form a bioactive interface between plants and numerous microorganisms. Fungi emit plethora of unique volatile compounds that belong to a number of chemical classes including alcohols, aldehydes, acids, ethers, ketones, hydrocarbons, terpenes, and sulfur compounds. VOCs are gases, carbon-based compounds having characteristic odors, and are produced during primary and secondary metabolism. The diverse functions of fungal VOCs can be used in biotechnological applications as biofuel, biocontrol, and mycofumigation.
References
Petrini O (1991) Fungal endophytes of tree leaves. In: Andrews JH, Hirano SS (eds) Microbial ecology of leaves. Springer, Berlin/Heidelberg/New York, pp 179–197
Hyde KD, Soytong K (2008) The fungal endophyte dilemma. Fungal Divers 33:163–173
Bacon CW, White JF (2000) Microbial endophytes. Marcel Dekker, New York, pp 341–388
Strobel GA (2006) Muscodor albus and its biological promise. J Ind Microbiol Biotechnol 33:514–522
Arnold AE (2007) Understanding the diversity of foliar endophytic fungi: progress, challenges, and frontiers. Fungal Biol Rev 21:51–66
Huang WY, Ca YZ, Hyde KD, Corke H, Sun M (2008) Biodiversity of endophytic fungi associated with 29 traditional Chinese medicinal plants. Fungal Divers 33:61–75
Huang WY, Cai YZ, Surveswaran S, Hyde KD, Corke H, Sun M (2009) Molecular phylogenetic identification of endophytic fungi isolated from three Artemisia species. Fungal Divers 36:69–88
Oses R, Valenzuela S, Freer J, Sanfuentes E, Rodriguez J (2008) Fungal endophytes in xylem of healthy Chilean trees and their possible role in early wood decay. Fungal Divers 33:77–86
Raghukumar C (2008) Marine fungal biotechnology: an ecological perspective. Fungal Divers 31:19–35
Strobel GA, Long DM (1998) Endophytic microbes embody pharmaceutical potential. ASM News 64:263–268
Carroll GC (1988) Fungal endophytes in stems and leaves: from latent pathogen to mutualistic symbionts. Ecology 69:2–9
Nisa H, Kamili AN, Nawchoo IA, Shafi S, Shameem N, Bandh SA (2015) Fungal endophytes as prolific source of phytochemicals and other bioactive natural products: a review. Microb Pathog 82:50–59
Priti V, Ramesha BT, Singh S, Ravikanth G, Ganeshaiah KN, Suryanarayanan TS, Shaanker RU (2009) How promising are endophytic fungi as alternative sources of plant secondary metabolites? Curr Sci 97(4):477–478
Strobel G, Daisy B (2003) Bioprospecting for microbial endophytes and their natural product. Microbiol Mol Biol Rev 67(4):491–502
Zhang HW, Song YC, Tan RX (2006) Biology and chemistry of endophytes. Nat Prod Rep 23:753–771
Tan RX, Zou WX (2001) Endophytes: a rich source of functional metabolites. Nat Prod Rep 18:448–459
Strobel GA, Daisy BH, Castillo U, Harper J (2004) Natural products from endophytic microorganisms. J Nat Prod 67:257–268
Strobel GA, Torczynski R, Bollon A (1997) Acremonium sp. a leucinostatin A producing endophyte of European yew (Taxus baccata). Plant Sci 128:97–108
Gunatilaka AAL (2006) Natural products from plant-associated microorganisms: distribution, structural diversity, bioactivity, and implication of their occurrence. J Nat Prod 69:509–526
Verma VC, Kharwar RN, Strobel GA (2009) Chemical and functional diversity of natural products from plant associated endophytic fungi. Nat Prod Commun 4:1511–1532
Strobel GA (2006) Harnessing endophytes for industrial microbiology. Curr Opin Microbiol 9:240–244
Mitchell AM, Strobel GA, Hess WM, Vargas PN, Ezra D (2008) Muscodorcrispans, a novel endophyte from Ananas ananassoides in the Bolivian Amazon. Fungal Divers 31:37–43
Strobel GA (2002) Microbial gifts from the rain forest. Can J Phytopathol 24:14–20
MacMillan J (2002) Occurrence of gibberellins in vascular plants, fungi and bacteria. J Plant Growth Regul 20:387–442
Sanders IR (2004) Plant and arbuscular mycorrhizal fungal diversity are we looking at the relevant levels of diversity and are we using the right techniques? New Phytol 164:415–418
Gonthier P, Gennaro M, Nicolotti G (2006) Effect of water stress on endophytic mycota of Quercus robur. Fungal Divers 21:69–80
Krings M, Taylor TN, Hass H, Kerp H, Dotzler N, Hermsen EJ (2007) Fungal endophytes in a 400-million-yr-old land plants: infection pathways, spatial distribution, and host response. New Phytol 174:648–657
Rodrigues KF, Samuels GJ (1990) Preliminary study of endophytic fungi in a tropical palm. Mycol Res 94:827–830
Rodrigues KF, Samuels GJ (1992) Idriella species endophytic fungi in palms. Mycotaxon 43:271–276
Liu XY, Xie XM, Duan JX (2007) Colletotrichum yunnanense sp. nov., a new endophytic species from Buxus sp. Mycotaxon 100:137–144
Peterson SW, Vega FE, Posada F, Nagai C (2005) Penicillium coffeae, a new endophytic species isolated from a coffee plant and its phylogenetic relationship to P. fellutanum, P. thiersii and P. brocae based on parsimony analysis of multilocus DNA sequences. Mycologia 97:659–666
Bertoni MD, Cabral D (1991) Ceratopycnidiumbaccharidicola sp. nov., from Baccharis coridifolia in Argentina. Mycol Res 95:1014–1016
Arenal F, Platas G, Pelaez F (2007) A new endophytic species of Preussia (Sporormiaceae) inferred from morphological observations and molecular phylogenetic analysis. Fungal Divers 25:1–17
Jacob M, Bhat DJ (2000) Two new endophytic conidial fungi from India. Cryptogam Mycol 21:81–88
Dhargalkar S, Bhat DJ (2009) Echinosphaeria pteridis sp. nov. and its Vermiculariopsiella anamorph. Mycotaxon 108:115–122
Singh SK, Gaikwad VP, Waingankar VM (2005) A new endophytic Thielaviaicacinacearum (ascomycete) isolated from medicinal plant Nothapodytes nimmoniana. J Basic Appl Mycol 4:68–70
Singh SK, Gaikwad VP, Waingankar VM (2009) A new endophytic ascomycete Gnomoniellapongamiae from healthy leaves of Pongamia pinnata Merr. Indian Phytopathol 62(1):124–125
Mirjalili MH, Farzaneh M, Bonfill M, Rezadoost H, Ghassempour A (2012) Isolation and characterization of Stemphylium sedicola SBU-16 as a new endophytic taxol-producing fungus from Taxus baccata grown in Iran. FEMS Microbiol Lett 328:122–129
Bills GF, Polishook JD (1992) Recovery of endophytic fungi from Chamaecyparis thyoides. Sydowia 44:1–12
Li H, Qing C, Zhang Y, Zhao Z (2005) Screening for endophytic fungi with antitumour and antifungal activities from Chinese medicinal plants. World J Microbiol Biotechnol 21:1515–1519
Hyde KD (2001) Where are the missing fungi? In: Hyde KD (ed) Mycological research. Cambridge University Press, 105:1422–1518
Hawksworth DL (1991) The fungal dimension of biodiversity: magnitude, significance, and conservation. Mycol Res 95:641–655
Hawksworth DL (2001) The magnitude of fungal diversity: the 1.5 million species estimate revisited. Mycol Res 105:1422–1432
Dreyfuss MM, Chapela IH (1994) Potential of fungi in the discovery of novel, low molecular weight pharmaceuticals. In: Gullo VP (ed) The discovery of natural products with therapeutic potential. Butterworth-Heinemann, Stoneham, pp 49–80
Frohlich J, Hyde KD (1999) Biodiversity of palm fungi in the tropics: are global fungal diversity estimates realistic? Biodivers Conserv 8:977–1004
Arnold AE, Maynard Z, Gilbert GS, Coley PD, Kursar TA (2000) Are tropical fungal endophytes hyperdiverse? Ecol Lett 3:267–274
Hammond PM (1992) In: Groombridge B (ed) Global biodiversity: status of the Earth’s living resources. Chapman and Hall, London, pp 17–39
May RM (1994) Conceptual aspects of the quantification of the extent of biological diversity. Philos Trans R Soc Lond Ser B 345:13–20
Rossman AY (1994) A strategy for an all-taxa inventory of fungal diversity. In: Chen CH, Peng CI (eds) Biodiversity and terrestrial ecosystems, Monograph series no 14. Institute of Botany, Academia Sinica, Taipei, pp 169–194
Arnold AE, Maynard Z, Gilbert GS (2001) Fungal endophytes in dicotyledonous neotropical trees: patterns of abundance and diversity. Mycol Res 105:1502–1507
Cannon PF, Simmons CM (2002) Diversity and host preference of leaf endophytic fungi in the Iwokrama Forest Reserve, Guyana. Mycologia 94:210–220
Suryanarayanan TS, Murali TS, Venkatesan G (2002) Occurrence and distribution of fungal endophytes in tropical forests across a rainfall gradient. Can J Bot 80:818–826
Mittermeier RA, Myers N, Gil PR, Mittermeier CG (1999) Hotspots: Earth’s biologically richest and most endangered terrestrial ecoregions. Cemex, Conservation International and Agrupacion Sierra Madre, Monterrey
Strobel G, Daisy B (2003) Bioprospecting for microbial endophytes and their natural products. Microbiol Mol Biol Rev 67:491–502
Xiong ZQ, Yang YY, Zhao N, Wang Y (2013) Diversity of endophytic fungi and screening of fungal paclitaxel producer from Anglojap yew, Taxus x media. BMC Microbiol 13:71–80
Brown KB, Hyde KD, Guest DJ (1998) Preliminary studies on endophytic fungal communities of Musa acuminata species complex in Hong Kong and Australia. Fungal Divers 1:27–51
Yeh YH, Kirschner R (2014) Sarocladium spinificis, a new endophytic species from the coastal grass Spinifex littoreus in Taiwan. Bot Stud 55:25
Proudfoot JR (2002) Drugs, leads and drug-likeness: an analysis of some recently launched drugs. Bioorg Med Chem Lett 12:1647–1650
Schulz B, Boyle C (2005) The endophytic continuum. Mycol Res 109:661–686
Schulz B, Boyle C, Draeger S, Rommert AK, Krohn K (2002) Endophytic fungi: a source of novel biologically active secondary metabolites. Mycol Res 106:996e1004
Santos RM, Rodrigues G, Fo E, Rocha WC, Teixeira MFS (2003) Endophytic fungi from Melia azedarach. World J Microbiol Biotechnol 19:767–770
Owen NL, Hundley N (2004) Endophytes e the chemical synthesizers inside plants. Sci Prog 87(2):79–99
Tejesvi MV, Nalini MS, Mahesh B, Parkash SH, Kinni RK, Shetty S (2007) New hopes from endophytic fungal secondary metabolite. Bol Soc Quim Mex 1:19–26
Tenguria RK, Khan FN, Quereshi S (2011) Endophytes e mines of pharmacological therapeutics. World J Sci Technol 1(5):127–149
Priti V, Ramesha BT, Singh S, Ravikanth G, Ganeshaiah KN, Suryanarayanan TS (2009) How promising are endophytic fungi as alternative sources of plant secondary metabolites? Curr Sci 97:477–478
Herrmann A (2010) The chemistry and biology of volatiles. Wiley, Chichester
Pagans E, Font X, Sanchez A (2006) Emission of volatile organic compounds from composting of different solid wastes: abatement by biofiltration. J Hazard Mater 131:179–186
Hodgson E, Levi PE (1997) A textbook of modern toxicology, 2nd edn. Appleton and Lange, Stamford, pp 1–496
Chiron N, Michelot D (2005) Odeurs de champignons: chimie et rôledans les interactions biotiques- une revue. Cryptogam Mycol 26:299–364
Korpi A, Jarnberg J, Pasanen A-L (2009) Microbial volatile organic compounds. Crit Rev Toxicol 39:139–193
Lemfack MC, Nickel J, Dunkel M, Preissner R, Piechulla B (2014) VOC: a database of microbial volatiles. Nucleic Acids Res 42:D744–D748
Kramer R, Abraham W-R (2012) Volatile sesquiterpenes from fungi: what are they good for? Phytochem Rev 11:15–37
Kesselmeier J, Kuhn U, Wolf A, Andreae MO, Ciccioli P, Brancaleoni E, Frattoni M, Guenther A, Greenberg J, De Castro VP, de Oliva T, Tavares T, Artaxo P (2000) Atmospheric volatile organic compounds (VOC) at a remote tropical forest site in central Amazonia. Atmos Environ 34:4063–4072
Leff JW, Fierer N (2008) Volatile organic compound (VOC) emissions from soil and litter samples. Soil Biol Biochem 40:1629–1636
Bäck J, Aaltonen H, Hellén H, Kajos MK, Patokoski J, Taipale R, Pumpanen J, Heinonsalo J (2010) Variable emissions of microbial volatile organic compounds (VOCs) from root-associated fungi isolated from Scots pine. Atmos Environ 44:3651–3659
Schulz S, Dickschat JS (2007) Bacterial volatiles: the smell of small organisms. Nat Prod Rep 24:814–842
Junker RR, Tholl D (2013) Volatile organic compound mediated interactions at the plant-microbe interface. J Chem Ecol 39:810–825
Piechulla B, Degenhardt J (2014) The emerging importance of microbial volatile organic compounds. Plant Cell Environ 37:811–812
Bennett JW, Hung R, Lee S, Padhi S (2013) Fungal and bacterial volatile organic compounds; an overview and their role as ecological signaling agents. In: Hock B (ed) The Mycota IX fungal interactions. Springer, Heidelberg/Berlin, pp 373–393
Bitas V, Kim HS, Bennett JW, Kang S (2013) Sniffing on microbes: diverse roles of microbial volatile organic compounds in plant health. Mol Plant-Microbe Interact 26:835–843
Wheatley RE (2002) The consequences of volatile organic compound mediated bacterial and fungal interactions. Antonie Van Leeuwenhoek 81:357–364
Griffin MA, Spakowicz DJ, Gianoulis TA, Strobel SA (2010) Volatile organic compound production by organisms in the genus Ascocoryne and a re-evaluation of myco-diesel production by NRRL 50072. Microbiology 156:3814–3829
Ezra D, Jasper J, Rogers T, Knighton B, Grimsrud E, Strobel GA (2004) Proton-transfer reaction- mass spectroscopy as a technique to measure volatile emissions of Muscodor albus. Plant Sci 166:1471–1477
Dunn WB, Ellis DI (2005) Metabolomics: current analytical platforms and methodologies. Trends Anal Chem 24:285–294
Morath SU, Hung R, Bennett JW (2012) Fungal volatile organic compounds: a review with emphasis on their biotechnological potential. Fungal Biol Rev 26(2–3):73–83
Spakowicz DJ, Strobel SA (2015) Biosynthesis of hydrocarbons and volatile organic compounds by fungi: bioengineering potential. Appl Microbiol Biotechnol l99:4943–4951
Bennett JW, Inamdar AA (2015) Are some fungal volatile organic compounds (VOCs) mycotoxins? Toxins 7:3785–3804
Siddiquee S (2017) Fungal volatile organic compounds: emphasis on their plant growth-promoting. In: Choudhary D, Sharma A, Agarwal P, Varma A, Tuteja N (eds) Volatiles and food security. Springer, Singapore
Acknowledgments
I, Humeera Nisa, would like to thank my research supervisor and mentor, Prof Azra N. Kamili, Head/Director, Department of Environmental Sciences/CORD, University of Kashmir, for her precious attention, valuable suggestions, and constant encouragement throughout the course of my PhD investigations. Only at her first rendezvous with me during the initial period of my MPhil study, several years ago, she foresaw my amateur scientific instincts. And now this work of ours is another effort to work deeper with the fungal endophytes.
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Nisa, H., Kamili, A.N. (2019). Fungal Endophytes from Medicinal Plants as a Potential Source of Bioactive Secondary Metabolites and Volatile Organic Compounds: An Overview. In: Jha, S. (eds) Endophytes and Secondary Metabolites. Reference Series in Phytochemistry. Springer, Cham. https://doi.org/10.1007/978-3-319-76900-4_29-1
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