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Stress Ulcer Prophylaxis in the Critically Ill Oncology Population

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Oncologic Critical Care

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Abstract

Stress-related mucosal disease in the critically ill population can lead to clinically important gastrointestinal bleeding. Common risk factors for the development of clinically important bleeding include invasive mechanical ventilation for greater than 48 h, coagulopathy, and multiorgan failure. Gastric acid suppression with proton pump inhibitors or histamine-2 receptor antagonists are commonly prescribed in intensive care units for stress ulcer prophylaxis. However, use of stress ulcer prophylaxis is not without risk and has been associated with Clostridium difficile infection and pneumonia. Factors inherent to malignancy and/or treatment may pose additional risk for clinically important bleeding as well as infection in the critically ill oncology population. This chapter will provide an evidence-based review of stress ulcer prophylaxis as well as considerations in the critically ill oncology population.

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Authors and Affiliations

  1. Clinical Pharmacy Specialist – Critical Care/Nutrition Support, Division of Pharmacy, The University of Texas MD Anderson Cancer Center, Houston, TX, USA

    Reagan D. Collins

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  1. Reagan D. Collins
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Correspondence to Reagan D. Collins .

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Editors and Affiliations

  1. Department of Critical Care, University of Texas MD Anderson Cancer C Department of Critical Care, Houston, TX, USA

    Joseph L. Nates

  2. Department of Critical Care, University of Texas MD Anderson Cancer C Department of Critical Care, Houston, TX, USA

    Kristen J. Price

Section Editor information

  1. Clinical Pharmacy Svcs, Pharmacy Clinical Programs, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    Todd W. Canada

  2. Clinical Pharmacy Specialist – Critical Care / Nutrition Support, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA

    Jeffrey J. Bruno

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Collins, R.D. (2019). Stress Ulcer Prophylaxis in the Critically Ill Oncology Population. In: Nates, J., Price, K. (eds) Oncologic Critical Care. Springer, Cham. https://doi.org/10.1007/978-3-319-74698-2_28-1

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