Abstract
The collection of blood from volunteer donors is done manually and also by automated apheresis devices. Donors are given relevant information about the collection process and testing performed and sign a consent form. If the donor is qualified to donate, a collection is performed, and the unit may be further processed to obtain red cells, plasma, and platelets following strict good manufacturing practices if the donation was whole blood. Testing for RBC alloantibodies, ABO type, and infectious diseases is performed; other testing such as HLA and neutrophil antibodies may be added. Units are stored at determined conditions and transfused as appropriate. Modifications such as leukoreduction, irradiation, and washing are performed routinely or according to clinical need.
References
Auten JD, Lunceford NL, Horton JL, Galarneau MR, Galindo RM, Shepps CD, Zieber TJ, Dewing CB. The safety of early fresh, whole blood transfusion among severely battle injured at US marine corps forward surgical care facilities in Afghanistan. J Trauma Acute Care Surg. 2015;79:790–6.
Berzuini A, Spreafico M, Prati D. One size doesn’t fit all: should we reconsider the introduction of cold-stored platelets in blood bank inventories? F1000Res. 2017;6:95.
Ellingson KD, Sapiano MRP, Haass KA, Savinkina AA, Baker ML, Chung KW, Henry RA, Berger JJ, Kuehnert MJ, Basavaraju SV. Continued decline in blood collection and transfusion in the United States-2015. Transfusion. 2017;57(Suppl 2):1588–98.
Freireich EJ, Lichtiger B, Mattiuzzi G, Martinez F, Reddy V, Kyle Wathen J. A prospective, randomized, double-blind study, comparing unirradiated to irradiated white blood cell transfusions in acute leukemia patients. Leukemia. 2012;27:861.
Price TH, Boeckh M, Harrison RW, McCullough J, Ness PM, Strauss RG, Nichols WG, Hamza TH, Cushing MM, King KE, Young JA, Williams E, McFarland J, Holter Chakrabarty J, Sloan SR, Friedman D, Parekh S, Sachais BS, Kiss JE, Assmann SF. Efficacy of transfusion with granulocytes from G-CSF/dexamethasone-treated donors in neutropenic patients with infection. Blood. 2015;126:2153–61.
Spinella PC, Pidcoke HF, Strandenes G, Hervig T, Fisher A, Jenkins D, Yazer M, Stubbs J, Murdock A, Sailliol A, Ness PM, Cap AP. Whole blood for hemostatic resuscitation of major bleeding. Transfusion. 2016;56(Suppl 2):S190–202.
Standards for Blood Banks and Transfusion Services. 31st ed. Bethesda: AABB; 2018.
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Martinez, F., Fedda, F. (2019). Blood Components. In: Nates, J., Price, K. (eds) Oncologic Critical Care. Springer, Cham. https://doi.org/10.1007/978-3-319-74698-2_201-1
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DOI: https://doi.org/10.1007/978-3-319-74698-2_201-1
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